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Transcript
BICH107/GENE105 Key Points Prions and Protein Folding • Protein structure (primary, secondary, tertiary) • Proteins have many possible conformations (ways to fold up into a 3D structure) • Proteins can spontaneously fold into the correct (biologically functional) 3D structure demonstrated by Christian Anfinsen in the 1950’s • -helix and -sheet are forms of secondary structure (repeating patterns of hydrogen bonds) • Diseases of protein folding Alzheimer’s Disease Huntington’s Disease Parkinson’s Disease Mad Cow Disease Creutzfeldt-Jacob Disease Kuru • Folded and misfolded (disease causing) proteins can have the same amino acid sequence • Some protein folding diseases are caused by prions prions are misfolded proteins that induce correctly folded proteins to misfold • Stanley Prusiner won the Nobel Prize in Physiology or Medicine in 1997 for his work on prions
