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Transcript
Oxidative Medicine and Cellular Longevity Special Issue on Glutathione: The Cellular Function—Maintaining Tripeptide CALL FOR PAPERS Glutathione (GSH), a tripeptide of glycine, cysteine, and glutamate, is a major cellular antioxidant that neutralizes free radicals and reactive oxygen species, detoxifies reactive electrophile products of lipid peroxidation, and maintains the thiol status of proteins. When GSH reacts with oxidants, it is oxidized to its disulfide form (GSSG), and thus the glutathione redox ratio (GSSG/GSH) is considered as an index of oxidative stress. GSH also regulates critical cellular processes, such as DNA synthesis and immune function, via redox sensitive factors. Furthermore, GSH is an essential biomolecule involved in other physiological processes, including xenobiotics detoxification, molecular signaling, redox regulation, and posttranslational modification of proteins. Altered GSH metabolism has been implicated in many diseases, such as cancer, cystic fibrosis, alcoholic and nonalcoholic fatty liver disease, Alzheimer’s disease, and diabetes. The long historic research and broad interest in GSH require an update in this field. Lead Guest Editor Guo-Fang Zhang, Duke University, Durham, USA [email protected] Guest Editors Takhar Kasumov, Northeast Ohio Medical University, Rootstown, USA [email protected] Vishwanath Venketaraman, Western University of Health Sciences, Pomona, USA [email protected] Potential topics include but are not limited to the following: Glutathione analysis in biological samples Regulation of glutathione synthesis and turnover Pathological mechanisms of glutathione depletion Glutathione as a signaling molecule Glutathione and protein modification Glutathione and immune function Diseases related to altered glutathione metabolism Dietary intake of glutathione or precursors of glutathione and/or dietary supplements Authors can submit their manuscripts through the Manuscript Tracking System at http://mts.hindawi.com/submit/journals/omcl/gsh/. Stephanie Harris, Case Western Reserve University, Cleveland, USA [email protected] Manuscript Due Friday, 14 July 2017 First Round of Reviews Friday, 6 October 2017 Publication Date Friday, 1 December 2017