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Oxidative Medicine and Cellular Longevity
Special Issue on
Glutathione: The Cellular Function—Maintaining
Glutathione (GSH), a tripeptide of glycine, cysteine, and glutamate, is a major cellular
antioxidant that neutralizes free radicals and reactive oxygen species, detoxifies
reactive electrophile products of lipid peroxidation, and maintains the thiol status of
proteins. When GSH reacts with oxidants, it is oxidized to its disulfide form (GSSG),
and thus the glutathione redox ratio (GSSG/GSH) is considered as an index of
oxidative stress. GSH also regulates critical cellular processes, such as DNA synthesis
and immune function, via redox sensitive factors. Furthermore, GSH is an essential
biomolecule involved in other physiological processes, including xenobiotics detoxification, molecular signaling, redox regulation, and posttranslational modification
of proteins. Altered GSH metabolism has been implicated in many diseases, such
as cancer, cystic fibrosis, alcoholic and nonalcoholic fatty liver disease, Alzheimer’s
disease, and diabetes. The long historic research and broad interest in GSH require
an update in this field.
Lead Guest Editor
Guo-Fang Zhang, Duke University,
Durham, USA
[email protected]
Guest Editors
Takhar Kasumov, Northeast Ohio
Medical University, Rootstown, USA
[email protected]
Vishwanath Venketaraman, Western
University of Health Sciences, Pomona,
[email protected]
Potential topics include but are not limited to the following:
Glutathione analysis in biological samples
Regulation of glutathione synthesis and turnover
Pathological mechanisms of glutathione depletion
Glutathione as a signaling molecule
Glutathione and protein modification
Glutathione and immune function
Diseases related to altered glutathione metabolism
Dietary intake of glutathione or precursors of glutathione and/or dietary
Authors can submit their manuscripts through the Manuscript Tracking System at
Stephanie Harris, Case Western Reserve
University, Cleveland, USA
[email protected]
Manuscript Due
Friday, 14 July 2017
First Round of Reviews
Friday, 6 October 2017
Publication Date
Friday, 1 December 2017