Download Immune Worksheet Session 27- 4/7/11

Leader: Ivy
Course: AnS 214
Instructor: Keating
Immune System
Session 27
Supplemental Instruction
Date: 4/7/11
Iowa State University
COMPLEMENT:
1) What part of the immune system (innate, adaptive) is complement a part of?
2) What are the major functions of complement?
3) Compare the two pathways in which complement is activated:
Classical Pathway
Alternative Pathway
Activated by…
Results in…
4) What is the major function of the following components of complement?
C3a:
C3b:
MAC:
FEVER:
1) T/F: Fever is always a dangerous thing for the human body.
2) What are the benefits of fever?
3) What are the dangers of a high fever?
4) What are responsible for resetting the body’s thermostat upward?
Where do these come from?
ADAPTIVE IMMUNITY (general):
1) What are the 3 key characteristics of the adaptive immune response?
2) Name and define the two overlapping arms of adaptive immunity:
ANTIGENS:
1) Compare the two types of antigens of the adaptive immune system:
Complete Antigens
Immunogenic?
React in
response to…
Incomplete Antigens (Haptens)
Examples
2) What is an antigenic determinant?
3) How are MHC proteins related to antigens?
4) Where would you find Class I MHC proteins?
Where would you find Class II MHC proteins?
LYMPHOCYTES:
1) Compare/contrast the two types of lymphocytes:
B cells
T cells
Humoral or Cellular
Immunity?
Originate in…
Mature in…
Exported to…
Major Functions
2) In positive selection, what happens if the T cell recognizes the self-MHC?
In positive selection, what happens if the T cell fails to recognize the self-MHC?
3) In negative selection, what happens if the T cell recognizes the self-antigen?
In negative selection, what happens if the T cell fails to recognize the self-antigen?
4) What happens to self-reactive B cells?
ANTIGEN-PRESENTING CELLS:
1) What is the function of APC’s?
2) What are some examples of APC’s?
ANTIBODIES:
1) Where do antibodies come from?
2) What is the functional region of the antibody (recognize antigens)?
3) What region of the antibody determines antibody class, binding, and antigen elimination?
4) Name the 5 classes of antibodies and the major function for each: