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Example of the Course Test 2 10th December, 8:00, registration from 7:30 - for the test you must be registered in SIS you must have your personal ID (no ISIC number) and credit book! the test will contain: 20 questions multiplechoice 4 short answers - examples of the questions are : 1) Choose true statements a) reaction: CH3-CO-COOH + NAD+ + HSCoA -> CO2 + NADH + H+ + CH3-CO~SCoA describes a decarboxylation of oxaloacetate b) glucose can be metabolised to lactate in erythrocytes c) insulin activates only anabolic pathways d) adenylate kinase catalyzes this reaction: ADP + ADP = AMP + ATP 2) Choose true statements a) NAD+ is one of the coenzymes in fatty acid synthesis b) secretion of adrenaline from the adrenal gland leads to glycemia elevation due to release of free glucose from muscles because glycogen cleavage by glycogenphosphorylase c) glycogen phosphorylase synthesises glycogen from glucose-6-phosphate d) glycerol formed by triacylglycerol degradation can be used as a substrate for gluconeogensis 3) Choose true statements a) fumaric acid can be oxidised to succinic acid b) converstion of malate to oxaloacetate is an oxidation c) conversion of ethanol to acetic acid is an oxidation d) conversion of fumarate to malate involves an addition of water 4) Out of the following choose correct statements a) lipases belong among transferases b) if an enzyme is characterised by a high value of the Michaelis constant (Km) it follows that the lower the substrate concentration, the higher the rate of the reaction c) allosteric enzymes often function as regulatory enzymes of metabolic pathways d) if Km of enzyme E1 is higher than Km of enzyme E2 it follows that enzyme E1 has a higher affinity for substrate than enzyme E2 5) Out of the following choose correct statements a) Maple syrup disease is one of inherited disorders of amino acid metabolism b) Enzyme homogentisate dioxygenase is dysfunctional in alkaptonuria c) Galactosemia is caused by the inability to degrade sphingolipid d) Enzyme tyrosinase is dysfunctional in albinism 6) Choose true statements a) Mitochondrion is semiautonomous organelle b) Outer mitochondrial membrane allows the protein transport into mitochondrion using specific TOM complexes c) Mitochondrial proteosynthetic apparatus is identical with the one in the cytoplasm d )Impairment of the cellular metabolism of energy may cause the death of cell 7) Choose true statements a) both kinesin and dynein are involved in the function of mitotic spindle b) dyneins move to the plus end of microtubules c) microtubules of a flagellum are anchored by their minus end in a basal body d) dynein molecule has two globular GTP-binding heads for the interaction with microtubules