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Cellular Respiration Part 3 Krebs Cycle – Pages 96 to 97 Chemically Grooming Pyruvate • 3 steps to Krebs Cycle ▫ Carbon atom is removed (3C to 2C) and released as CO2 ▫ 2C compound is oxidized while NAD+ is reduced to NADH ▫ Coenzyme A joins with 2C to form acetyl co-A Fig. 9-10 CYTOSOL MITOCHONDRION NADH + H+ NAD+ 2 1 Pyruvate Transport protein 3 CO2 Coenzyme A Acetyl CoA Krebs Cycle (Citric Acid Cycle) • Called the Citric Acid Cycle because Citric Acid (citrate) is the 1st molecule formed in the cycle • Called the Krebs Cycle after Hans Krebs – the researcher who discovered it • Occurs in the matrix of the mitochondria • Involves 2 electron carriers – NADH and FADH2 • The cycle oxidizes organic fuel derived from pyruvate, generating 1 ATP, 3 NADH, and 1 FADH2 per turn Fig. 9-11 Pyruvat e CO2 NAD+ CoA NADH + H+ Acetyl CoA CoA CoA Citric acid cycle 2 CO2 FADH2 3 NAD+ 3 NADH FA D + 3 H+ ADP + ATP Pi Summary of Krebs Cycle • 2C of acetyl Co-A joins with 4C of OAA to form 6C citrate; Co-A is recycle • Thru a series of energy extracting reactions 2CO2, 3NADH, 1FADH2 + 1 ATP are produced per turn • Remaining 4C molecule is rearranged to form OAA Fig. 9-12-8 Acetyl CoA Products for 1 turn including grooming: 4 NADH 1 FADH2 1 ATP 3 CO2 CoA—SH NADH +H NAD H2O 1 + + 8 Oxaloacetate 2 Malate Citrate Isocitrate NAD H2O + Citric acid cycle 7 Fumarate 6 3 CO2 CoA— SH 4 CoA— SH 5 FADH2 NAD FAD + Succinate GTP Pi GDP ADP ATP NADH + H+ Succinyl CoA NADH + H+ -Ketoglutarate CO2 Products for 1 glucose including grooming: 8 NADH 2 FADH2 2 ATP 6 CO2