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• • • • • • Generalised anxiety disorder Panic disorder Phobias Somatoform disorders Management of SMI in primary care Developments in medication Generalised anxiety disorder Core symptoms • Tension • Worry • Apprehension Autonomic arousal symptoms • Palpitations • Sweating • Trembling • Dry mouth Generalised anxiety disorder Symptoms concerning chest and abdomen • Difficulty breathing • Feeling of choking • Chest pain or discomfort • Nausea or abdominal distress Symptoms concerning brain and mind • Dizziness • Derealization/Depersonalisation • Fear of losing control, going crazy, or passing out • Fear of dying Generalised anxiety disorder Symptoms of tension • Muscle tension or aches and pains • Restlessness • Feeling on edge • Dysphagia General symptoms • Hot flushes or cold chills • Numbness/tingling Other non-specific symptoms • Easily startled • Difficulty concentrating • Irritability • Difficulty getting to sleep because of worry Generalised anxiety disorder (DSM5) • having a number of different worries that are excessive and out of proportion to a particular situation • difficulty controlling worries • other symptoms – – – – – – Restlessness or feeling keyed up or on edge. Being easily fatigued. Difficulty concentrating or mind going blank. Irritability. Muscle tension. Sleep disturbance. NICE: Consider diagnosis of GAD in… • people presenting with anxiety or significant worry • in people who attend primary care frequently who: – have a chronic physical health problem or – do not have a physical health problem but are seeking reassurance about somatic symptoms (particularly older people and people from minority ethnic groups) or – are repeatedly worrying about a wide range of different issues. NICE: Treatment of GAD • Self help • Psychological treatment – CBT – Applied relaxation • Medication – – – – – SSRI SSRI or SNRI Pregabalin (Antipsychotics) (Benzodiazepines) • (Psychosocial stressors) Panic attack • Sudden onset • • • • Intense apprehension, fear, or terror Feelings of impending doom Feelings of unreality Fear of dying, losing control, or going mad • • • • Palpitations Chest pain Choking sensations Dizziness Panic disorder Persistent panic attacks with Fear of future attack and/or Maladaptive change in behaviour to avoid attack NICE: Treatment of panic disorder • Self help • CBT • Medication – SSRI (?high doses) – Imipramine/Clomipramine (12 week trials) • (Psychosocial stressors) Phobic (expected) anxiety • Specific triggers • Anticipatory anxiety • Avoidance Agoraphobia Social phobia Specific phobia Treat with CBT Trigger Perceived threat Anxiety Catastrophic misinterpretation Physical/mental symptoms Co-morbidities • Depression • Alcohol/substance misuse (inc. caffeine&nicotine) • Somatoform disorders/Hypochondriasis • Timelines • Severity • Treat alcohol/substance misuse first (if possible) Somatoform disorders (MUPS) • Focus on therapeutic relationship – feel understood – broaden agenda – make links – agree further treatment • Reduce iatrogenic harm • Stress reduction • CBT Primary Care follow up of SMI • • • • • Condition stable Self-management established Clear treatment plan Relapse signature/contingency plan Rapid access to secondary care SMI annual review • • • • • • How is your mental health? And your physical health? Are you facing any major stresses? Any new side effects from medication? Are you happy with your treatment? Offer annual physical health check Developments with medication: Antipsychotics Atypical antipsychotics • Treatment of bipolar depression • Prophylaxis of bipolar disorder • Augmentation of antidepressants All antipsychotics increase risk of stroke Atypical vs conventional? Developments with medication: Antidepressants • • • • Moderate to severe/chronic depression only Bleeding Teratogenicity New drugs – Agomelatine – Vortioxetine – Escitalopram Developments with medication: Mood Stabilisers Lithium • First line for prophylaxis of bipolar disorder Valproate • No longer first line in bipolar disorder • High teratogenic risk Lamotrigine • Treatment of bipolar depression