Download Chapter 4. Functional Group Transformations: Oxidation and

Chapter 4. Functional Group Transformations:
Oxidation and Reduction
4.1 Oxidation of Alcohols to aldehyde and Ketones
Classical oxidation is using chromium(VI) reagent.
Oxidation of primary alcohol to aldehyde requires anhydrous conditions.
Table 4.1 Methods for Alcohol Oxidation
Name
Reagents
Z
Jones
Swern
Dess-Martin
TEMPO
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The E2-like process is supported by the observation that deuterium
substitution of the α-H in isopropanol slows the rate of chromic acid
oxidation by seven fold.
Since C-D bonds are broken more slowly than C-H bond, these
results suggest that the α-H is removed in a slow step.
4.2 Reagents and Procedure for Alcohol Oxidation
Jones reagent
Excellent reagent for the oxidation of secondary alcohol that do not
contain acid-sensitive groups such as acetals.
Primary alcohol can be converted into carboxylic acid by oxidation of
initially formed aldehyde followed by further oxidation.
Excess Cr(VI) is destroyed in the reaction workup by adding some
isopropyl alcohol (color change from orange to blue green)
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The reaction can be performed even in the presence of water.
Collins-Ratcliff reagent: mild reagent for the oxidation of alcohols that contain
acid sensitive groups.
Pyridinium Chlorochromate (PCC)
If alcohol contains acid sensitive group, powedered NaOAc is added.
Pyridinium Dichromate (PDC): the reaction can be carried out at neutral conditions.
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in DMF
Swern Oxidation:
If formation of chlorinated side products is a problem, the Swern oxidation can
be performed with DMSO, P2O5, and Et3N.
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Dess-Martin Periodinane (DMP) Oxidation
KHSO5
Oxidation of 2-iodobenzoic acid with Oxone (2KHSO3-KHSO4-K2SO4)
furnishes the oxidizing agent o-iodoxybenzoic acid, IBX, a periodinane.
IBX is explosive when heated >130oC. Acetylation of IBX with Ac2O in
the presence of a catalytic amount of TsOH produces the Dess-Martin
periodinane, DMP.
This reaction is suitable for multifunctional substrates containing acid-sensitive
groups.
Merits compared with Cr(VI)- and DMSO based oxidants
1) relative easy preparation, 2) short reaction time, 3) simplified workups
4) lower toxicity
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Tetrapropylammonium Perruthenate (TPAP)
TPAP tolerates a wide variety of functional groups, including double
bonds, enones, halides, epoxides, esters, and lactones.
Protecting groups, such as MEM, trityl, silyl and benzyl ethers,
THP and acetals, are not affected.
4.3 Chemoselective agents for oxidizing alcohols
MnO2 is a highly chemoselective oxidant-allylic, benzylic, and propargyl
alcohols are oxidized faster than saturated alcohols.
Solvent: H2O, acetone, or CHCl3.
Low reactivity: use large amount of oxidant
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Barium Manganate: more readily available and does not require special treatment.
Silver Carbonate on Celite
The ease oxidation follows: allylic, benzylic-OH>2o ROH> 1o ROH
Highly hindered alcohol is not oxidized.
Lactol can be transformed into lactone.
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2,2,6,6-Tetramethyl-1-piperidinyloxy (TEMPO): commercially available radical
With oxidants
Chiral center is not affected
Oxidation of secondary alcohol is much slower.
Ceric ammonium nitrate
Triphenylcarbenium tetrafluoroborate
Oxidation of secondary alcohol over primary alcohol
The secondary over primary selectivity results from preferential formation of
an oxocarbenium ion intermediate at the secondary center (R2+C-OTr is
formed faster than RH+C-OTr)
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Sodium Hypochlorite
4.4 Oxidation of Acyloins (α-hydroxy ketone) to α-diketone
stoichiometric
Catalytic with ammonium nitrate
Bismuth Sesquioxide in the presence of acetic acid
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4.5 Oxidation of tertiary allylic alcohols (The Babler Oxidation)
A carbonyl transposition can be effected via addition of a vinyl or an
alkyl Grignard reagent to an α,β-unsaturated ketone.
-OCrO3
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4.6 Oxidative Procedure to Carboxylic acid
Oxidation of aldehyde
to carboxylic acid
4.7 Allylic Oxidation of Alkene
Selenium Dioxide
Alkenes possessing allylic C-H bonds are oxidized by SeO2 either to allylic
alcohols or esters or to α,β-unsaturated aldehyde or ketones. The reaction
involves ene type reaction followed by sigmatropic [2,3]-shift.
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Lower yield of products were obtained when using stoichiometric amount
of SeO2. t-Butyl hydroperoxide is used to reoxidize selenium.
Chromic Anhdride: powerful oxidant suitable for allylic oxidation of electrondeficient alkenes.
t-Butyl Peroxybenzoate: copper(I) salts catalyze the allylic oxidation of
alkenes in the presence of peresters, such as tert-BuO2COPh, to afford
the corresponding allylic benozate esters.
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The mechanism is believed to involve addition of an allylic radical
to copper(I) benzoate. Rearrangement of the copper(III) intermediate then
produces the product and regenerates the copper(I) catalyst.
4.8 Terminology for reduction of carbonyl compounds.
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Prochiral center is a trigonal carbon of C=O and C=C that is not a
stereogenic center but can be made chiral by addition reactions.
Objects and molecules are said to be homochiral when they possess the
same sense of chirality. For example, L-alanine and its methyl ester
derivative shown below are said to be homochiral.
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4.9 Nucleophilic Reducing reagents
The majority of reductions of carbonyl compounds and nitriles with
nucleophilic reducing reagents, such as M[AlH4] and M[BH4], proceed
via nucleophilic transfer of a hydrogen atom with two electrons called a
“hydride” from the reducing agent to the carbonyl or cyano carbon.
The rate of reduction and the chemoselectivity of a reducing agent toward
a given substrate depends on factors such as
1. the nature of the metal cation (Li+, Na+, Zn2+), which serves as a Lewis
acid to activate the carbonyl or cyano moiety toward hydride transfer.
2. substitution of the reducing agent hydrogens by alkyl, -OR, or –CN groups
3. the reaction medium (Et2O, THF, ROH, H2O)
4. the reactivity order of substrates is: RCHO>R2CO>RCO2R’>RCONR2>RCO2H
Aluminum Hydride
Lithium Aluminum Hydride-LiAlH4
Powerful reducing agent but not very chemoselective.
It must be used in nonprotic solvents such as Et2O or THF.
To decompose any excess Al-H, first add ethyl acetate, followed by
methanol and then H2O.
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The reduction of esters to primary alcohols and the reduction of amides
to amines requires two hydrides, whereas reduction of caboxylic acids to
primary alcohols consumes three hydrides.
Reference Table 4.2
Lithium Trialkoxyaluminum Hydride- Li[AlH(OR)3]
They are less reactive but more selective than LAH and are best
prepared just prior to use in situ.
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Borohydrides
Sodium Borohydride: a mild, selective reducing agent, its handling does
not require special precautions. EtOH is usually the solvent of choice.
It reduces RCHO and R2CO in EtOH or aqueous solutions rapidly at 25oC
to the corresponding alcohols.
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The Li+ cation is stronger Lewis acid than the Na+ cation. Li+ coordination
with the carbonyl group enhances the electrophilicity of the carbonyl cation.
Thereby facilitating hydride transfer. Lithium borohydride is a more powerful
reducing agent than sodium borohydride: it reduces esters to primary alcohol
but is unreactive towards amides.
Sodium Cyanoborohydride-NaBH3CN
Because of the presence of the electron withdrawing cyano group,
NaBH3CN is less nucleophilic and hence is more selective than NaBH4.
The utility of NaBH3CN as a reducing agent is greatly enhanced by its
stability toward low pH (stable to pH 3).
In acidic condition, carbonyl reduction does occur (protonated
carbonyl group)>
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NaBH3CN is a chemoselective reducing agent. For example, it is possible
to selectively reduce an aldehyde in the presence of keto group or a
keto group in the presence of an ester group using NaBH3CN.
Reductive Amination with NaBH3CN
Since the reduction of an iminium salt by NaBH3CN occurs more readily
than the reduction of a carbonyl group, NaBH3CN is the reagent of choice
for the reductive amination of aldehyde and ketones.
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4.10 Electrophilic Reducing Agents
Whereas nucleophilic reducing agents react fast with electron-deficient
carbonyl groups, the reactivity of electrophilic reducing agents such as
R2AlH and BH3, characterized by their coordination with the carbonyl
oxygen prior to hydride transfer, favor reductions of electron-rich carbonyl
groups.
Diisobutylaluminum hydride (DIBAL-H)
Reductions with DIBAL-H must be carried out in the absence of air and
moisture. DIBAL-H is a very versatile reagent for the selective reduction
of appropriately substituted esters or nitriles to the corresponding
aldehyde and for the reduction of lactones to lactole.
Reduction of Esters to Aldehyde
A neighboring alkoxy group will stabilize the tetrahedral intermediate through
chelation and prevent overreduction.
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Reduction of Nitriles to Aldehyde
Borane•Tetrahydrofuane and Borane•Dimethylsulfide
Commercially available
These reagents can do facile reduction of carboxylic acids to
primary alcohols, and selective reduction of a –CO2H group
in the presence of other functional groups.
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Thexylchloroborane
Table 4.3 Selectivity in BH3•THF Reduction
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4.11 Regio- and Chemoselective Reductions
1,2-Additions: iBu2AlH, Zn(BH4)2, (i-PrO)2TiBH4, 9-BBN,
CeCl3-NaBH4 (Luche reagent)
K-Selectride reduces β-unsubstituted cyclohexenones to cyclohexanones
(1,4-addition) and β-substituted cyclohexenones to the corresponding allylic
alcohols (1,2-additions).
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Aldehyde is more reactive than ketone with K[BH(OAc)3].
A
l
d
e
Initial acetalization
for the protection
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Reduction of carboxylic acids in the presence of Ketones or esters.
4.12 Diasterreoselective Reduction of Cyclic Ketones
This reaction is called Meerwein-Ponndorf-Verley (MPV) reduction, which
involves treatment of ketone with aluminum triisopropoxide [Al(OCHMe2)3].
This is an equilibrium process favoring the more stable stereoisomer.
In the case of an alkyl-susbtituted cyclohexanone is the equatorial alcohol.
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