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FOUNDATION MODULE 2012 SELF ASSESMENT BCQs 6TH WEEK (DEVELOPMENT AND GENETICS) Q1)Regarding transcription following is incorrect? d) It is a process of formation of DNA from RNA** Q2)Which of the following is not the function of sympathetic nervous system? c)Pupils are constricted. *** Q3)Which of the following neurotransmitter is released by preganglionic axons? c)Acetylcholine. *** Q4)Nucleotide triphosphtes required for transcription are: e)All*** Q5)Cranial outflow does not consist of the following nerve? c) Vestibulocochlear nerve (VIII). *** Q6)Gastrulation is characterized by a) Formation of mesoderm. *** Q7)Following are the requirements for transcription except d)DNA polymerase** Q8)Which of the following regarding parasympathetic nervous system is not true? e)The vasodilator fibres release epinephrine and norepinephrine.*** Q9)First sign of gastrulation is the formation of c) Primitive streak. *** Q10)Regarding post transcriptional modification of RNA incorrect is d) Eukaryotic mRNA is generally identical to its primary transcripts** Q11)Regarding the parasympathetic division of the autonomic nervous system, select the CORRECT statement: d) Parasympathetic postganglionic fibers secrete acetylcholine onto their target organs. *** Q12)The prechordal plate is the primordium of e)Oral cavity. *** Q13)Which of the following is TRUE of the sympathetic nervous system? c) It uses different neurotransmitters at the ganglion and at the synaptic cleft. *** Q14) Microsomal oxidation of Phase I Reactions include : e) Salicylates. ***** Q15)In Eukaryotic mRNA following is not correct b) Introns are the coding regions** Q16)Regarding genetic code: c) Methionine and tryptophan have only 1 codon*** Q17)Which statement is odd regarding Somites e) Square in shape on transverse section. *** Q18) Phase II reaction of drug metabolism includes: d) Conjugation ***** Q19)Neurulation involves formation of the : e) Neural tube.*** . Q20) Which is the major organ for the biotransformation of drugs? c) Liver. ***** Q21)Neural crest cells give rise to the following except: e) The suprarenal(adrenal cortex)*** Q22)Regarding initiation: c) Initiator factors facilitate the assembly of this initiation complex*** Q23)Ability of a drug to bind a receptor is called? e)Affinity*** Q24)Regarding acetylcholine: a. Binds with nicotinic receptors causing ionotropic effect*** Q25) Colchicine has receptor? b) Tubulin.*** Q26)Many metabolites of drugs created in the liver are excreted into the intestinal tract in? d) bile. *** Q27) In conservative theories of replication. b) One new strand is formed.*** Q28)Substances excreted in the feces usually involve orally ingested unabsorbed drugs or metabolites excreted in the bile that are not reabsorbed from the intestinal tract? d) intestinal tract*** Q29)Regarding epinephrine and nor epinephrine: b. Beta-blockers block beta receptors causing decrease in heart rate*** Q30)Receptors linked via G- proteins are typically? c) 7 transmembrane spanning domains.*** Q31) cGMP is a second messenger in? b)Vascular smooth muscle*** Q32) Regarding parasympathetic activation: d. Parasympathetic fibers cause vasodilation and are responsible for erection of the penis and cilitoris *** Q33) Ability of drug to produce pharmacological effect after binding to a receptor is called? b)Intrinsic ability.*** Q34)Organs that excrete drugs eliminate polar compounds (water soluble) more readily than components with high? a)Lipid solubility.** Q35)GABA receptor in the which is coupled to a chloride ion channel, can be modulated by anticonvulsants, benzodiazepines and barbiturates.? d)CNS** Q36)Regarding Sympathetic role: b) Stimulates the reticular activating system of the brain causing increased mental alertness*** Q37) Regarding Telomerase. d) Non- Coding sequence of DNA complex with proteins.*** Q38) In DNA polymerases function of POL α is a) Initiates DNA synthesis.*** Q39) Coffin-Lowry syndrome is caused by mutation in a) Ribosomal protein gene*** Q40)Changes in genomic sequence is termed as: d) Mutations.*** xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------------------------------xxxxxxxxxxxxxxxxxxxxxxx