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المملكة العربية السعودية وزارة التعليم العالي جامعة سلمان بن عبدالعزيز كلية العلوم الطبية التطبيقية الخرج Kingdom of Saudi Arabia Ministry of Higher Education Salman Bin Abdulaziz University College of Applied Medical Science AL-Kharj _________________________________________________________________________________ 1st Periodical Exam 2st Semester (1435- 1436H) Student Name: …………………………………………………………………………………………………………………………………… Student Number: ……………………………………………………………………………………………………………………………… Academic Year: Fourth Year Exam Title: Medical Genetic (MLAB 484) Exam Date: 8/5/1435H Time Allowed: 1 hr. Question Number Marks Maximum 1 12 2 3 3 (Bonus) 2 Total 15 Obtained (1) Read the following sentence and choose the correct answer (Mark 10/15): Lecture 1: Human genome and chromosomal basis of hereditary 1.1 Mitotic divisions produce two daughter cells with a _______ number of chromosomes, while meiosis produces four daughter cells with a _______ number of chromosomes. A. B. C. D. Haploid , diploid Diploid, haploid Haploid, haploid Diploid, diploid 1.2 During mitosis, the two sister chromatids move toward opposite poles during which stage? A. Prophase B. Anaphase C. Metaphase D. Telophase 1.3 Kintchore is: A. Specific region of the chromosome attaches and pull the chromosome during cell division B. Protein synthesis enzymes C. DNA synthesis enzyme D. Protein attached to microtubules of mitotic spindles 1.4 Most of the genetic changes that happen in our DNA during cell divisions are quickly repaired by: A. B. C. D. RNA repair system Protein repair system DNA repair system Check point proteins in our cells Lecture 2: Population Genetic and Evolution: 1.5 One statement is correct about founder population: A. It is larger than the parent population B. less rare allele or absent C. The effect of genetic drift will be small D. All of the above 1.6 Neo-Darwinian theory: allele's changes frequency in response to: 2 A. B. C. D. Correlation and migration Selection and random drift Migration and natural allele Selection and migration and random drift 1.7 Allelic frequencies for general population can be calculated using: A. B. C. D. Selection coefficient Bayesian risk calculation Hardy-Weinberg distribution None of the above Lecture 3: Genetic Variation 1.8 There are four possible types of mutations, but of the following is wrong, which is: A. B. C. D. Single base solution Insertions and deletions Chromosomal mutations Mitochondrial mutations 1.9 Mitochondrial disorders are caused by mtDNA that inherited by: A. B. C. D. The mothers The father The Grand parents Unknown 1.10 Most mutations are recognized because the ….. A. B. C. D. Phenotype Genotype Allelic variations HWD Lecture 4: Patterns of single gene inheritance: 3 1.11 Phenylketonuria is a genetic disorder that inherited as: A. B. C. D. Autosomal recessive Autosomal dominant X-linked Y- linked 1.12 If both parents are carriers for Autosomal recessive disorders, the chance that on their child by affected is: A. B. C. D. 50% 35% 20% 25% (2) Answer the following questions with True or False and correct the False (Mark 8/15): 2.1 Human genetic variability can be traced using either scientific trees or phylogenetic maps [ ] …………………………………………………………………………………………………………. 2.2 Cousin marriages are more likely to result in children affected by an autosomal recessive disorder than marriages between unrelated parents [ ] …………………………………………………………………………………………………………. 2.3 Members of pair of chromosomes described as homologous chromatids, which they carry matching genetic sequence [ ] …………………………………………………………………………………………………………. 2.4 Gene flow between populations as a result of migration is called population admixture [ 4 ] …………………………………………………………………………………………………………. 2.5 Ploidy is term that describes number of chromosome in cells, which they either diploid or haploid [ ] …………………………………………………………………………………………………………. 2.6 Thus in a pedigree in which a sex-linked mutation is segregating, the mutation is inherited through the male line and the resultant disorder present in every generations [ ] …………………………………………………………………………………………………………. 3) Bonus: If you chose to answer question three, you must answer both parts 3.1 and 3.2 (Mark 2) 3.1 Please calculate the risk of these siblings being carriers of Myotonic dystrophy, if one parent is carrier to that disease (Marks1/2): 5 3.2) Identify each figures (Marks1/2): 3.2.1 …………………………………………………….. 3.2.2 ……………………………………………………… 6