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‫المملكة العربية السعودية‬
‫وزارة التعليم العالي‬
‫جامعة سلمان بن عبدالعزيز‬
‫كلية العلوم الطبية التطبيقية الخرج‬
Kingdom of Saudi Arabia
Ministry of Higher Education
Salman Bin Abdulaziz University
College of Applied Medical Science AL-Kharj
_________________________________________________________________________________
1st Periodical Exam
2st Semester (1435- 1436H)
Student Name: ……………………………………………………………………………………………………………………………………
Student Number: ………………………………………………………………………………………………………………………………
Academic Year: Fourth Year
Exam Title: Medical Genetic (MLAB 484)
Exam Date: 8/5/1435H
Time Allowed: 1 hr.
Question
Number
Marks
Maximum
1
12
2
3
3 (Bonus)
2
Total
15
Obtained
(1) Read the following sentence and choose the correct answer (Mark 10/15):
Lecture 1: Human genome and chromosomal basis of hereditary
1.1 Mitotic divisions produce two daughter cells with a _______ number of chromosomes, while
meiosis produces four daughter cells with a _______ number of chromosomes.
A.
B.
C.
D.
Haploid , diploid
Diploid, haploid
Haploid, haploid
Diploid, diploid
1.2 During mitosis, the two sister chromatids move toward opposite poles during which stage?
A. Prophase
B. Anaphase
C. Metaphase
D. Telophase
1.3 Kintchore is:
A. Specific region of the chromosome attaches and pull the chromosome during cell division
B. Protein synthesis enzymes
C. DNA synthesis enzyme
D. Protein attached to microtubules of mitotic spindles
1.4 Most of the genetic changes that happen in our DNA during cell divisions are quickly repaired
by:
A.
B.
C.
D.
RNA repair system
Protein repair system
DNA repair system
Check point proteins in our cells
Lecture 2: Population Genetic and Evolution:
1.5 One statement is correct about founder population:
A. It is larger than the parent population
B. less rare allele or absent
C. The effect of genetic drift will be small
D. All of the above
1.6 Neo-Darwinian theory: allele's changes frequency in response to:
2
A.
B.
C.
D.
Correlation and migration
Selection and random drift
Migration and natural allele
Selection and migration and random drift
1.7 Allelic frequencies for general population can be calculated using:
A.
B.
C.
D.
Selection coefficient
Bayesian risk calculation
Hardy-Weinberg distribution
None of the above
Lecture 3: Genetic Variation
1.8 There are four possible types of mutations, but of the following is wrong, which is:
A.
B.
C.
D.
Single base solution
Insertions and deletions
Chromosomal mutations
Mitochondrial mutations
1.9 Mitochondrial disorders are caused by mtDNA that inherited by:
A.
B.
C.
D.
The mothers
The father
The Grand parents
Unknown
1.10 Most mutations are recognized because the …..
A.
B.
C.
D.
Phenotype
Genotype
Allelic variations
HWD
Lecture 4: Patterns of single gene inheritance:
3
1.11 Phenylketonuria is a genetic disorder that inherited as:
A.
B.
C.
D.
Autosomal recessive
Autosomal dominant
X-linked
Y- linked
1.12 If both parents are carriers for Autosomal recessive disorders, the chance that on their child by
affected is:
A.
B.
C.
D.
50%
35%
20%
25%
(2) Answer the following questions with True or False and correct the False (Mark 8/15):
2.1 Human genetic variability can be traced using either scientific trees or phylogenetic maps [
]
………………………………………………………………………………………………………….
2.2 Cousin marriages are more likely to result in children affected by an autosomal recessive disorder
than marriages between unrelated parents [
]
………………………………………………………………………………………………………….
2.3 Members of pair of chromosomes described as homologous chromatids, which they carry
matching genetic sequence [
]
………………………………………………………………………………………………………….
2.4 Gene flow between populations as a result of migration is called population admixture [
4
]
………………………………………………………………………………………………………….
2.5 Ploidy is term that describes number of chromosome in cells, which they either diploid or haploid
[
]
………………………………………………………………………………………………………….
2.6 Thus in a pedigree in which a sex-linked mutation is segregating, the mutation is inherited
through the male line and the resultant disorder present in every generations [
]
………………………………………………………………………………………………………….
3) Bonus: If you chose to answer question three, you must answer both parts 3.1 and 3.2
(Mark 2)
3.1 Please calculate the risk of these siblings being carriers of Myotonic dystrophy, if one parent is
carrier to that disease (Marks1/2):
5
3.2) Identify each figures (Marks1/2):
3.2.1 ……………………………………………………..
3.2.2 ………………………………………………………
6