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Unit 7 Objectives Heredity Chapters 14 and 15 At the conclusion of this unit, you should be able to: List several features of Mendel’s methods that contributed to his success. State four components of Mendel’s hypothesis of inheritance. Describe Mendel’s law of segregation. Use a Punnett square to predict the results of monohybrid and/or dihybrid crosses and state the phenotypic and genotypic ratios of each. 5. Distinguish between genotype and phenotype, heterozygous and homozygous, dominant and recessive traits. 6. Use the laws of probability to calculate the chances of an individual having a specific genotype or phenotype. 7. Describe the inheritance of the ABO blood system and explain why the A and B alleles are said to be codominant. 8. Define and give an example of pleiotropy. 9. Distinguish between penetrance and expressivity. 10. Given a simple family pedigree, deduce the genotypes for the family members. 11. Describe the inheritance and expression of cystic fibrosis, Tay Sachs disease, and sickle cell anemia. 12. Explain how a lethal recessive gene can be maintained in a population. 13. Explain why consanguinity increases the probability of homozygousity in the offspring. 14. Explain why lethal dominant genes are much rarer than lethal recessive ones. 15. Explain how carrier recognition, fetal testing and newborn screening can be used in genetic screening and counseling. 16. Define: P1, F1, F2, Barr body, Klinefelters, Turners syndrome, Huntington’s chorea, trisomy, cru di chat, achondroplastic dwarfism, aneuploidy, and phenocopy. 17. Complete genetics problems related to the condition and patterns of inheritance discussed. 18. Understand the use of the Chi Square test in studying data from genetic crosses. 1. 2. 3. 4.