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Name_________________________ Date__________ DNA Construction Problem: What does a model of DNA look like? Materials: Tracing Paper Scissors String Meter Stick Construction Paper Markers, crayons or colored pencils Tape or glue Heavy colored blank paper Procedure: 1.) Trace the figures for the Deoxyribose sugar and the Phosphate group onto tracing paper. Out of construction paper, cut out 24 Deoxyribose figures and 24 Phosphate figures. Use one color for the Deoxyribose figures and another color for the Phosphate figures. Label them with an “S” for Deoxyribose sugar and a “P” for Phosphate group on both sides of the figures. P S 2.) Trace the four nitrogen bases shown below with tracing paper. A A C T G Name ________________________________________________ 3.) Cut out the four tracings and copy each part onto heavy paper to make Use: Yellow for “T”- Thymine Green for “G”- Guanine 6 copies of each Pink for “A”- Adenine Blue for “C” - Cytosine 4.) Label each nitrogen base with the correct letter (A,T,G,C). Label on both sides of the figure. 5.) Measure and cut out two 2 meter lengths of string. Tape down one length of the string at both ends onto your work area. 6.) Start from the end of the taped down string, place a Sugar, then a Phosphate, alternating with the sugars and phosphates, and then tape the 12 Sugars and 12 Phosphates on each string. For the other string, start with a Phosphate and end with a sugar. 7.) To each Sugar on one strand, tape a nitrogen base. 8.) To the other strand, arrange the remaining nitrogen bases according to how they will pair following the rules of nitrogen base pairing. Tape them in the proper order to the Sugar and then tape or glue them to the corresponding nitrogen base on the other strand of your DNA model. *** If you were not careful about how you distanced your pieces or taped them, they will not line up properly. If this is you, fix it!! We do not want any mutant DNA strands. Data and Observations: 1.) To the lines marked left and right strand, record the order of the bases on your DNA model? Left strand-- Right strand mRNA ____--____ _____ ____--____ _____ ____--____ _____ ____--____ _____ ____--____ _____ ____--____ _____ ____--____ _____ ____--____ _____ ____--____ _____ ____--____ _____ ____--____ _____ ____--____ _____ Amino Acid ___________________ ___________________ ___________________ ___________________ 2.) How is your DNA model (above) different from those of your classmates? Be specific please. 3.) In what ways is your entire DNA model similar to your classmates’ models? Again, be specific. Analysis: 1.) Where would you find this model if it were in a eukaryotic cell? ___________________________________ 2.) Should your model under DNA replication: a.) How many molecules of DNA will be produced ___________________________________ b.) What will the strands of DNA look like? __________________________________________ __________________________________________________________________________________________ 3.) Why did strings make your DNA model a more realistic model? Look at an image of DNA to help you out. 4.) 5.) Now to your strand on the previous page, transcribe the right strand of DNA to make mRNA. Remember the base pairing rules and that Uracil takes the place of Thymine. Using the Genetic code wheel below, translate your DNA’s message by filling in the amino acids on the previous page.