Download Gene Section FAM57A (family with sequence similarity 57, member A)

Atlas of Genetics and Cytogenetics
in Oncology and Haematology
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Gene Section
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FAM57A (family with sequence similarity 57,
member A)
Zhiao Chen, Xianghuo He
State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai, China (ZC,
XH)
Published in Atlas Database: August 2010
Online updated version : http://AtlasGeneticsOncology.org/Genes/FAM57AID40183ch17p13.html
DOI: 10.4267/2042/45013
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
© 2011 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Expression
Identity
CT120 is universally expressed in different human
normal tissues and in various human tumor cell lines.
Other names: CT120, FLJ22282
HGNC (Hugo): FAM57A
Location: 17p13.3
Localisation
CT120 is a novel plasma membrane-associated gene.
DNA/RNA
Function
Description
CT120 may assume very essential physiological
functions involving in amino acid transport and
glutathione metabolism through interaction with
SLC3A2 and GGTL3B.
Gene size: 2145 bp in length, ORF 774 bp.
Full-length cDNA of CT120/FAM57A contains 2145
base pairs and encodes a protein with 257 amino acids.
Homology
Transcription
Homology comparison revealed that CT120 is highly
conserved during biological evolution.
The CT120 contains two isoforms in human: one
isoform identified was termed CT120A; another
isoform (AAH26023.1) was named CT120B, which
consists of four exons and encodes a protein with 225
amino acids (the fourth exon in CT120A is spliced).
Implicated in
Lung cancer
Prognosis
CT120A protein was a potential molecular target for
treatment of lung cancers. CT120A was overexpressed
in 15 cases of the 16 primary lung cancer specimens.
Knockdown of CT120A by small hairpin RNA in the
human lung adenocarcinoma cell line SPC-A-1 cells
resulted in a reduced cell growth rate in vitro and
decrease of the capacity for anchorage-independent
growth and tumorigenicity in nude mice.
The suppression of CT120A expression also sensitized
cells to ultraviolet-induced apoptosis. Atlas cDNA
expression array revealed that the expressions of
several apoptosis- and growth-associated genes were
altered underlying the molecular mechanisms of these
cell biological behaviors.
Protein
Description
- CT120: 257 aa; 29 kDa.
- CT120B: 225 aa; 25 kDa.
Atlas Genet Cytogenet Oncol Haematol. 2011; 15(5)
408
FAM57A (family with sequence similarity 57, member A)
Chen Z, He X
Oncogenesis
CT120 ectopic expression could promote cell
proliferation activity of NIH3T3 cells, and two major
signaling pathways involved in cell proliferation, cell
survival and anti-apoptosis were overexpressed and
activated in response to CT120: one is the
Raf/MEK/Erk signal cascades and the other is the
PI3K/Akt signal cascades, suggesting that CT120
might contribute, at least in part, to the constitutively
activation of Erk and Akt in human lung cancer cells.
In addition, some tumor metastasis associated genes
cathepsin B, cathepsin D, cathepsin L, MMP-2/TIMP-2
were also upregulated by CT120, upon which CT120
might be involved in tumor invasiveness and
metastasis.
In addition, CT120 might play an important role in
tumor progression through modulating the expression
of some candidate "lung tumor progression" genes
including B-Raf, Rab-2, BAX, BAG-1, YB-1 and
Cdc42.
References
He X, Di Y, Li J, Xie Y, Tang Y, Zhang F, Wei L, Zhang Y, Qin
W, Huo K, Li Y, Wan D, Gu J. Molecular cloning and
characterization of CT120, a novel membrane-associated gene
involved in amino acid transport and glutathione metabolism.
Biochem Biophys Res Commun. 2002 Sep 27;297(3):528-36
He XH, Li JJ, Xie YH, Tang YT, Yao GF, Qin WX, Wan DF, Gu
JR. Altered gene expression profiles of NIH3T3 cells regulated
by human lung cancer associated gene CT120. Cell Res. 2004
Dec;14(6):487-96
Pan DN, Li JJ, Wei L, Yao M, Wan DF, Gu JR. Inhibitory effect
of CT120B, an alternative splice variant of CT120A, on lung
cancer cell growth. Acta Biochim Biophys Sin (Shanghai). 2005
Sep;37(9):588-92
Pan D, Wei L, Yao M, Wan D, Gu J. Down-regulation of
CT120A by RNA interference suppresses lung cancer cells
growth and sensitizes to ultraviolet-induced apoptosis. Cancer
Lett. 2006 Apr 8;235(1):26-33
Li Z, Shao S, Xie S, Jiao F, Ma Y, Shi S. Silencing of CT120 by
antisense oligonucleotides could inhibit the lung cancer cells
growth. Ir J Med Sci. 2010 Jun;179(2):217-23
This article should be referenced as such:
Chen Z, He X. FAM57A (family with sequence similarity 57,
member A). Atlas Genet Cytogenet Oncol Haematol. 2011;
15(5):408-409.
Atlas Genet Cytogenet Oncol Haematol. 2011; 15(5)
409