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CHAPTER 13: THE
LYMPHATIC SYSTEM
AND IMMUNITY
A&P II HS130
Professor Tracy Abram, MAIS, BS
Objectives
• Function of Lymphatic System
• Discuss primary lymphatic structures
• Compare nonspecific and specific immunity
• Compare active and passive immunity
• Immune system
• Function of B and T Cells
Lymphatic and
Immune
These systems work
together to defend our
body and maintain
Homeostasis!
What do you know about Lymph?
• Clear fluid: enters through left and right subclavian veins
• Collects between cells throughout body
• Active part of Lymphatic system
• Passive movement in lymph vessels via muscle
contraction
How is lymph formed?
http://www.lymphnotes.com/article.php/id/1
51/
Lymph fluid
• Formed from blood plasma
• Blood plasma filters out of capillaries
• Between tissue cells
• Also known as tissue fluid or interstitial fluid
• ***Circulatory system plays a starring role in assisting the
• Lymphatic system
Figure 13-3 page 340
Right Lymphatic Duct
• Responsible for lymph
drainage from right upper
extremity, right side of
head, neck, and upper
torso
Thoracic Duct
• Largest lymphatic vessel
• Contains pouch: cisterna
chyli (see figure 13-1
page 338)
• Drains lymph from about
75% of the body
Lymph Nodes
Primary function:
Defense and WBC
producer
Clusters that vary in size
along lymphatic vessel
Professor Abram’s Scenario Time!
• Artemio, Mary, Veronica, and Nikita go to this fancy, virtual
restaurant for dinner. Everyone orders their food: chicken
wings, sushi, rice, seaweed salad, peas and carrots,
steak, and salad. They are having a marvelous time
discussing A&P II when Artemio suddenly gets sick and
runs to the restroom (diarrhea).
• What do you think happened to Artemio?
Thymus
Endocrine gland and
Lymphoid Tissue Organ
Produces T-cells (Tlymphocytes)
Secretes thymosin
(hormone)
Vital to Immune Response
PubMed. Immunol Rev.
2002 Jul;185:7-14.
The discovery of thymus
function and of thymusderived lymphocytes.
http://www.ncbi.nlm.nih.gov/
pubmed/12190917
• http://www.webmd.com/oralTonsils
Made of 3 masses of
lymphoid issue around
opening of mouth and
throat
Three types of tonsils:
•
Palatine- “tonsils”
•
Pharyngealadenoids
•
Lingual
health/picthttp://www.webmd.
com/oral-health/picture-ofthhttp://www.webmd.com/oral
-health/picture-of-thetonsilse-tonsilsure-of-thetonsils
Spleen
Largest Lymphatic
Organ
Location: Upper left
quadrant of abdominal
area
Functions: Phagocytosis
of bacteria and “old
junkyard” for RBCs
Immune System
• What do you know about the Immune System?
Answer: Immune System
• Protects body from bacteria, foreign tissue cells, and
cancerous cells
• Made of groups of organs, cells, and molecules
• Let’s discuss the different types…shall we?
Nonspecific vs Specific Immunity
• Nonspecific
• Specific
• Innate immunity
• Adaptive Immunity
• Skin
• Two types: Natural and
• Tears and mucus
• Inflammation (figure
13-8 page 344)
Artificial Immunity
INNATE AND NON-SPECIFIC
IMMUNITY
Khanacademy.org. (2010, February 18). Role
of Phagocytes in Innate and Nonspecific
immunity. [YouTube].Retrieved from
http://www.youtube.com/watch?v=O1N2rENX
q_Y
Natural Immunity
• Active:
• active disease
produces immunity
• **not deliberate
• Passive
• Immunity passed from
mother to fetus via
placenta or breast milk
Artificial Immunity
• Active
• Passive
• Vaccination results in
• Protection developed
immunity
• ***deliberate exposure
in another individual’s
immune system and
given to non-immune
person
Immune System Molecules
• What are antibodies?
• What is humoral or antibody-mediated complex?
• Figure 13-9 page 346
• How do Complement Proteins work?
• Figure 13-10
Let’s Play the Matching Game!
• 1. lymphocytes
• 2. Kupffer’s cells
• 3. Monocyte
• 4. Neutrophil
• 5. B lymphocyte
• 6. T lymphocyte
• 7. Thymus
• 8. Spleen
• 9. Lymph
• 10. Lymph nodes
a. Numerous cells of immune system
b. Immune defense
c. liver macrophage
d. secrete antibodies
e. Most numerous granulytes
f. does not secrete antibodies, but attacks bacteria
g. plasma fluid
h. WBC formation and defense
i. Junkyard for RBCs
j. endocrine gland