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There are 1,000,000,000,000 (one trillion) cells in the immune system It takes 1,000,000,000 (one billion) cancer cells to form a barely detectable lump. No medical equipment on earth can detect even 1,000,000 (one million) cancer cells in a patient. Therefore, “I think we got it all” can best be translated, “I can’t see or feel anymore cancer, so let’s hope the immune system will destroy that which is probably still there.” acrophage Frontline defender Housekeeper Herald to helper T cells Helper T cell Commander-in-Chief Identifies enemy Recruits all other cells Stimulates spleen & lymphocyte cell growth Killer T cell Kills cells invaded by enemy Kills cancer cells as they appear B cells From spleen or lymph nodes Produce chemical weapons (antibodies) which hit specific enemy targets Suppressor T cell A third T cell that slows or stops B cells or other T cells when the battle is won Memory T cell Made during first infection; stays for years to enable rapid response to invasion by same enemy Aspirin Blocks Important Mechanisms Aspirin inhibits the formation of prostaglandin E in the midbrain. Since prostaglandin E is the body’s agent to set in motion the fever response, giving aspirin blocks a fever. Yet a fever activates several defense mechanisms and should not be carelessly brought down. If the physiological mechanisms of fighting germs are stimulated at the same time a fever is reduced, the act of bringing down the fever is a result of lessening toxicity, a thing of the body’s own doing. Healthy Immune System-I Resting pulse below 80 Daily exercise to point of sweating White blood count below 5,500 Pale urine from abundant water drinking Healthy Immune System-II Regularity in all things Moderate sunning early morning, late day Warm arms and legs, summer and winter A Healthy Immune System Reduce Stress and Enhance Immunity by Creative Expression • Writing • Music • Painting • Lecturing Increases Lymphocyte Response to Bacteria and Viruses Reference: Dr. James W. Pennebaker, et. Al. - SMU Immature Immune System • • • • Protect it ! Keep warm No tight bands around body (leaving red marks) Avoid an unhappy home Breastfeed - reduces asthma, allergies, increases IQ • Slow down maturation • Avoid drugs, hospitalization • Keep the mind free from loads Forms of Stress • Chemical - allergies and food sensitivities, contact with environmental toxins (smoke, fumes, mold, unpleasant odors) • Mental - physical pain, indecision, worry about physical condition, noise, work conditions, marital problems • Emotional - a serious loss, either actual or threatened, fear, empty nest, social factors • • • • • • • • Vinegar, alcohol, aspirin Sugar, rich foods Allergens Coffee, tea & colas Black pepper Spices Drugs Baking powder & soda Natural killer cells increase in number and ability to fight cancer cells if animals in experimental studies are restricted in their food to approximately 60%. Food restricted mice have strong anticancer immunity and as a result cancer growth is suppressed and survival time prolonged in these mice. Journal of Nutrition, 130:111, 2000 Anticancer foods • • • • • • Cabbage family Garlic Dark green vegetables Peaches Soybeans All vegetables • • • • • • Tomatoes Citrus Apples Spinach All beans All fruits Design Your Diet • Citrus fruits • Garlic • Flaxseed (lignans: anti- • Parsley estrogen activity) • Soybeans (isoflavones) • Celery & carrots • Asparagus A Healthy Immune System • Freedom of mind – • Elevated spirits - freedom from jealousy, anxiety, remorse, guilt, grief, discontent, distrust, long hours at work Courage, faith, love,contentment, hope, sympathy, rejoicing, trust • Daily creative expression - 20 minutes in writing, music, painting, landscaping, lecturing • Live in the knowledge of truth • Reduce your stresses • Avoid drugs 25 20 24 15 18 14 10 10 5 0 6 0 12 5.5 2 1 Sugar Bacteria Teaspoonsful of sugar vs. number of bacteria able to be killed in a half hour by one WBC • A healthy immune system will usually spot and kill mutated cells before they turn cancerous. • Exercise boosts strength of natural killer cells. • Walking boosts the immune system and helps the body destroy viruses. • Non-exhausting workouts spark immune system. • Moderate exercise can shield you from disease. • Vigorous exercise provides biggest boost. • Vigorous exercisers get sick less often. • Exhausting exercise weakens immunity. o Physical activity speeds the passage of waste and reduces colon exposure to cancercausing compounds. o Exercise helps maintain low levels of insulin which may stimulate the growth of colon cancer Consumer Reports on Health, February 1999 The more estrogen in a woman’s body during her lifetime, the greater her risk of breast cancer Exercise indirectly lowers the release of estrogen Exercise can reduce body fat, another source of estrogen Consumer Reports on Health, February 1999 Regular exercise reduced levels of testosterone; testosterone appears to fuel the growth of prostate cancer. Consumer Reports on Health, February 1999 Astragalus – Polysaccharides stimulate WBC activity and boost production of antibodies and interferon (a natural anti-viral agent). Goldenseal – Anti-microbial properties and antibiotic substance (berberine) fight infections. Elderberry– Antiviral; increases blood circulation and promotes sweating, detoxifies cell tissues. Echinacea – Antiviral and antibacterial action. Boosts immunity by raising: T cell and neutrophil levels; macrophage phagocytosis, antibody binding, natural killer cell activity. Grapefruit Seed Extract – Kills or inhibits growth of bacteria, fungi, viruses, and protozoan parasites. Diseases Increasing WBCs Name Approx. healthy % Diseases Causing Increase Neutrophils 60 Acute bacterial infections, surgical wounds, bruising, childbirth, meat or milk diet, exercise, fever, leukemia Lymphocytes 40 Viral diseases, antibody formation, leukemia Monocytes 1-5 Chronic inflammation Eosinophils 1-5 Allergies Basophils 1-2 Leukemia Plasma Cells Platelets 0 Adequate Cancer of the bone marrow, chronic inflammation Hemolytic disorders Its Effects on Immunity “As people age, they tend to become more susceptible to infections.” • • • Changes in T Cells Total number of T • lymphocytes remains constant, but there are • changes in certain subsets Overall decline in T-cell function with increasing age Capacity to produce interleukin-2 (which stimulates proliferation and differentiation of other T- • cells) declines Why? Thymus atrophy occurs Diminution of thymic hormones T cell response to new antigens declines. Most T cells have had prior antigenic exposure (memory T cells); explains why elderly people respond to antigens previously encountered, but not to new antigens Response to antigens is more sluggish (Terpenning & Bradley: Why Aging Leads to Increased Susceptibility to Infection. Geriatrics Feb 1991) Scarlet Fever: England & Wales 2500 Mean annual death rate of children under 15 2000 1500 96% decline before sulfonamides 1865-1935 1000 Rates per 100,000 inhabitants Sulfonamides 500 1860 1870 1880 1890 1900 1910 1920 1930 1940 1950 3.2 3 2.8 Poliomyelitis: Dominican Republic 2.6 From 1980-1983 Poliomyelitis morbidity rate declined naturally 98.5% 2.4 2.2 2 1.8 1.6 1.4 Rates per 100,000 inhabitants 1.2 EPI Introduced (OPV Vaccine) 1 0.8 0.6 0.4 0.2 0 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 Whooping Cough: 1400 1200 Mean annual death rate of children under 15 1000 800 600 400 200 98.5% Decline before pertussis vaccine generally available 1868-1953 Rates per 100,000 inhabitants 0 England & Wales Immunization Generally Available Measles: England & Wales 1300 1100 1200 Mean annual death rate of children under 15 1000 900 800 700 600 500 400 300 200 100 0 1850 Virtual 100% decline 1855-1965 Rates per 100,000 inhabitants 1860 1870 1880 1890 1900 Immunizations Begun 1910 1920 1930 1940 1950 1960 1970 • Leads to tooth decay • Lowers disease resistance • Promotes constipation • High calories & low food value = weight gain • Causes vitamin B losses; affects mental health & emotions • Leads to CHD and mature-onset diabetes • Damages appestat, leading to overweight • Causes liver damage similar to alcohol • Clogs the system