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Transcript
BiochemistryCh 11. Carbohydrates (Cont.) 阮雪芬 NTUT Nov 18, 2002 ABO Blood Groups Glycosidic Bonds Between Proteins and Carbohydrates N-linked Oligosaccharides N-linked Oligosaccharides Elastase Protein Glycosylation Takes Place in the Lumen of the Endoplasmic Reticulum and in th Goligi Complex Transport Into The Endoplasmic Reticulum Golgi Complex as Sorting Center Formation of a Mannose 6phosphate Marker I-cell Disease: deficient in the phosphotransferase. Quality-control System for The Protein Folding in the ER Mass Spectrometric “sequencing” of Oligosaccharides Peptide N-glycosidase F Peptide N-glycosidase F, neuraminidase F and b1, 4-galatosidase Binding Selectivities of Plant Lectins Lectins are ubiquitous, being found in animals, plants, and microorganisms. The chief of lectins in animals is to facilitate cell-cell contact. C-type in Animals A calcium ion acts as a bridge between the protein and sugar through direct interactions with sugar hydroxyl groups. Selectins Mediate Cell-cell Interactions L: lymph-node vessels E: endothelium P: activated blood platelets Structure of A Part of Influenza Hemagglutinin Influenza virus recognizes sialic acid residues present on cell-surface glycoproteins. The viral protein that binds to these sugars is called hemagglutinin. Neuraminidase Another viral protein, neuraminidase, cleaves the glycosidic bonds to the sialic acid residues, freeing the virus to infect the cell. Inhibitor of this enzyme are showing some promise as anti-influenza agents.