* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Bi Polar Affective Disorder
Separation anxiety disorder wikipedia , lookup
Factitious disorder imposed on another wikipedia , lookup
Autism spectrum wikipedia , lookup
History of psychiatric institutions wikipedia , lookup
Rumination syndrome wikipedia , lookup
Glossary of psychiatry wikipedia , lookup
Panic disorder wikipedia , lookup
Excoriation disorder wikipedia , lookup
Mental disorder wikipedia , lookup
Antipsychotic wikipedia , lookup
Abnormal psychology wikipedia , lookup
Classification of mental disorders wikipedia , lookup
Diagnostic and Statistical Manual of Mental Disorders wikipedia , lookup
Mental status examination wikipedia , lookup
Antisocial personality disorder wikipedia , lookup
Postpartum depression wikipedia , lookup
Dissociative identity disorder wikipedia , lookup
Depersonalization disorder wikipedia , lookup
History of mental disorders wikipedia , lookup
Emergency psychiatry wikipedia , lookup
Child psychopathology wikipedia , lookup
Asperger syndrome wikipedia , lookup
Generalized anxiety disorder wikipedia , lookup
Controversy surrounding psychiatry wikipedia , lookup
Biology of depression wikipedia , lookup
History of psychiatry wikipedia , lookup
Conduct disorder wikipedia , lookup
Narcissistic personality disorder wikipedia , lookup
Spectrum disorder wikipedia , lookup
Conversion disorder wikipedia , lookup
Major depressive disorder wikipedia , lookup
Schizoaffective disorder wikipedia , lookup
Bipolar disorder wikipedia , lookup
Depression in childhood and adolescence wikipedia , lookup
BiPolar Affective Disorder Ratna Ghosh ST6, GA Psychiatry Cambridgeshire & Peterborough Foundation NHS Trust 20.8.09 What I am going to talk about • History • Epidemiology • Aetiology • Diagnosis • Treatment • Prognosis • ISQs History(1) • Hippocratic school: described melancholia and mania • Galen: black bile=melancholia; yellow bile=mania • In the middle ages, more theological and religious explanations for mental illness • Nineteenth century: French Psychiatrists: “la folie circulaire” • Kahlbaum : circular disorder characterised by episodes of both excitement and depression which did not end in dementia (cyclothymia) History(2) • Emil Kraeplin : separated manic-depressive • • • illness from dementia praecox by episodic course, benign outcome, family history; “Kraeplinian Dichotomy” Eugen Bleuler: Spectrum disorder; mood symptoms are non specific Kasanin : schizo-affective disorders Freud: mourning & melancholia History (3) • Current nosology is neo-krepaelinian • Validity of the diagnosis is derived from research on phenomenology, genetics, course, treatment response • Diagnostic subtypes (DSM-IV &ICD-10) Major Depressive (Unipolar) Disorder Bipolar Disorder( BPI , BPII, BPIII,? BPIV) Dysthymia; Cylcothymia ;( Hyperthymia ) Fig. 1 Two-dimensional mood/affective spectrum (does not include schizoaffective disorder, as a transition to the schizophrenic spectrum). The precise relationship of personality disorders to the disease spectra is uncertain and an unsolved general problem of psychiatric classification. BP-I (-II), bipolar-I disorder type I (II); D, major depression, d, minor depression; M, mania; m, hypomania; MDD, major depressive disorder; RBD, recurrent brief depression; sx, symptoms Angst, J. Br J Psychiatry 2007;190:189-191 Copyright © 2008 The Royal College of Psychiatrists Acute Mania • • • • • • • • • • • Elevated mood Irritable mood Increased self esteem or grandiosity Decreased need for sleep Increased talkativeness Flight of ideas Distractibility Increased social activities Psychomotor agitation Risk taking behaviour Increased sexual activites Clinical Features :Acute Mania (3 stages of acute mania in untreated patients*) • Hypomania: increased well being/ irritability, sufficient control over the condition; elevated mood (4/7)+psychomotor symptoms+ expansive; but able to function in social & occupational setting • Mania without psychotic features: elevated/ irritable mood (1/52), decreased need for sleep , psychomotor agitation, distractibility, increased social activities, increased talkativeness, flight of ideas, increased self esteem, risk taking behaviour, increased sexual activities. There is marked impairment in social & occupational functioning and hospital admission is often needed • Mania with psychotic features: emotional lability, extreme anger, hostility, severe agitation, no need for sleep, flight of ideas, grandiose delusions, sexually very preoccupied. Mood congruent/incongruent psychotic symptoms *Carlson& Goodwin, Arch of Gen Psych,28,221-8 Bipolar Disorder: recurrent episodes • BP I : episodes of mania+ episodes of major depression. 5-10% only recurrent mania • BP II: episodes of hypomania + episodes of major depression • BP III: cyclothymia (DSM-IV-TR) • ? BP IV: episodes of mania following treatment with antidepressant • ? BP V: episodes of depression with family history of BAD • ? BP VI : only episodes of mania or hypomania Bipolar Disorder • Rapid Cycling Disorder: at least 4 episodes of mania, depression, hypomania, mixed state in the past 12 months • Mixed Affective State: presence of manic and depressive symptoms in the same episode; duration at least 2 /52 Bipolar Disorder: chronic • Chronic mania: rare • Chronic bipolar major depression : major depression continuously for at least 2 years in a patient with a previous manic or hypomanic episode • Cyclothymia: sub-syndromal mood swings; persistent fluctuating mood disturbances Bipolar Depression • Family history of any bipolar disorder in first-degree relatives • Early age at onset • High frequency of depressive episodes • Psychotic features • Hypersomnia (atypical symptoms) • psychomotor retardation, anergia • Irritability & anger Epidemiology(1) • Data from USA National Institute of Mental • • • • • Health Epidemiologic Catchment Area Study (ECA)& National Co-morbidity survey National Psychiatric Morbidity Survey of GB Lifetime prevalence is 0.3-1.5% Bipolar Spectrum disorder: prevalence up to 6.4% Mean age of Onset : 17-27 years (not normally distributed with a peak in late teenage) Similar prevalence in males and females Epidemiology(2) • High co-morbidity: anxiety disorders (90%), alcohol(40%)& drug abuse/dependence(60%), conduct disorder, ADHD • Significant increase in lifetime health service utilisation • Greater marital disruption • 10% of patients commit suicide. Up to 40% patients have attempted suicide Aetiology • Genetic Factors • Organic factors • Iatrogenic • Life Events : childbirth • seasonal variation • Childhood factors +/- Genetic Aetiology of Bipolar Disorder • Family studies :Family studies of bipolar disorder, have shown increased familial risks of bipolar disorder, schizoaffective disorder, and unipolar depression. • Adoption studies : support familial aggregation(17% risk in biological parent vs 7% in adopted parent) • Twin studies :increased risk of bipolar disorder in monozygotic (identical) co-twins (50%)as compared to dizygotic (fraternal) cotwins (10%) of a proband with bipolar-I disorder • Molecular Genetics Molecular Genetics • • • • Chromosomes 8,9,10,13,14,22,18 Small positive effect size Often negative on replication Meta analysis have provided some support for polymorphism in genes involved in MAO,COMT,5HT metabolism; ? Genes for ion channelopathy • some of the regions identified in linkage studies of bipolar disorder overlap with regions implicated in schizophrenia • DISC1,neuregulin,BDNF (rapid cycling) genes could be involved (? Psychosis gene) • ANTICIPATION Neural correlates (affective disorder) • Neuropsychology • Neuro imaging • Neuropathology (PM) studies • Lesion studies implicate disturbances in the frontal lobe, basal ganglia, striatum and anterior temporal cortex. • Amygdala hyperactivation • Methodological issues • State/trait/effects of medication Psychosocial Aetiology • Life Events • Child birth • Social relationships • Dysfunctional cognition • Temperament & personality variables Course & Prognosis • Onset 15-19 years • Considerable time lag between first symptom(15),diagnosis(19),treatment(22) • Median length of episode 4-6 months • Chronic in 10% (over 24 months) • ?Kindling effect in recurrence • More episodes in bipolar illness (10 vs 4 in 22 year follow up) Course & Prognosis (2) • Higher recurrence if mixed/cycling feature • Remission is frequently incomplete • Residual symptoms are a strong risk factor(x3) for further recurrence • Longer term : recovery in 16%,chronic course in 11% • Co morbidity : 30% alcoholism • Mortality:15% Treatment • NICE Guidelines • BAP Guidelines Treatment of acute mania(not on anti manic) • Second generation antipsychotic : Olanzapine, quetiapine, risperidone • If no response, add Li or valproate • Consider Valproate or Lithium if previous good response and compliance (avoid valproate in women of child bearing age group) • Avoid CBZ Acute Mania ( patient on anti manic) • Optimise treatment dose (Li: 0.8-1.0) • Add olanzapine/quetiapine/risperidone Acute depression • SSRI + antimanic • Consider quetiapine • Consider Lamotrigine (BP II) Longer term treatment • If more than 2 episodes in BP I • If significant risk/functional impairment/frequent episodes in BP II • Lithium/valproate/olanzapine monotherapy • If no response in 6 months, consider combination of 2 of the above • If no response, add lamotrigine, CBZ • Antidepressants not routinely prescribed ISQs… 1. In bipolar affective disorder, mania & 2. 3. 4. depression may correlate with activation of distinct parts of the pre-frontal cortex Lithium may provide protection against some structural changes in the brain In bipolar affective disorder, amygdala is not affected The manic prodrome is idiosyncratic to each patient with bipolar affective disorder ANS: 1T.2T.3F.4T. 1. Patients with bipolar disorder have more minor/sub syndromal depressive symptoms than depressive episodes 2. Patients with bipolar disorder are symptomatic for up to 50% of the time 3. Lithium is equally effective in preventing manic and depressive relapses 4. Antidepressants may be less effective in the treatment of major depression than bipolar depression ANS 1T.2T.3F.4F. ISQ(3) 1. Bipolar disorder patients are less likely than 2. patients with major depressive disorder to experience psychosis during depressive episodes Antidepressants are associated with higher rates of depressive relapse on discontinuation in patients with bipolar disorder than in those with major depression Ans 1F 2T • Any Questions? • Thank You