Download Hemophilia

Hemophilia
By:
Abijah Minton
Alfredo Sugawara
Brandon Abad
Summary of Hemophilia
 Hemophilia is a disorder where your blood
doesn’t clot.
 It is a recessive trait.
 If a mom doesn’t have the gene for
hemophilia and the father does, their son will
not carry the trait for hemophilia but their
daughter will.
 Symptoms of hemophilia are excessive
bleeding. Other people may experience life
threatening hemorrhages with common
What Chromosome is your disorder
located on?
 This disorder is located on the x
chromosome.
Mode of Inheritance
 Someone would acquire hemophilia from
sex linked traits.
 If a trait is sex linked, then a gene is only
carried by the male or female parent. Not
by both.
Explaining Alleles
 An allele is any of several forms of a gene, usually




arising through mutation, that are responsible for
hereditary variation.
Alleles come from a female and male parent.
RR stands for dominant alleles. rr is a recessive
allele. Rr is the dominant gene over the recessive
gene.
The dominant gene produces the same phenotype
in the organism whether or not its allele identical.
The recessive gene produces its characteristic
phenotype only when its allele is identical.
Probability of Passing Down
Hemophilia
H
h
h
h
Hh
Hh
hh
hh
H
H
h
h
HH
Hh
Hh
hh
Probability Using Ratios And
Percentages
Ratios
2 :2
Hh : hh
Percentage
50%
: 50%
50% Hh : 50% hh
Hh
Hh
hh
hh
Explanations
 A capital H means that the allele for
Hemophilia is dominant, where as a
lowercase h means recessive.
 HH: Not Hemophilia, Hh: Not Hemophilia,
hh: Hemophilia
 HH: Homozygous Dominant, Hh:
Heterozygous Recessive, hh:
Homozygous Recessive
Genotype And Phenotype
Probability
Phenotype – Ratio: 2 Hemophiliacs to 2
Non- Hemophiliacs
– Percentage: 50% to 50%
Genotype – Ratio: 2 Hh to 2 hh
- Percentage: 50% Hh to 50% hh
Student Practice
Genotype:
H
h
H
HH
Hh
h
Hh
hh
Ratio: 1 : 2 : 1
Percentage: 25% : 50% : 25%
Phenotype:
Ratio: 3 : 1
Percentage: 75% : 25%
Hypothetical Pedigree
Key
Female
Hemophiliac
Female
Male
Hemophiliac
Male
Key
Male
Hemophiliac
Male
Female
Hemophiliac
Student Practice
Female
2. How many females in this pedigree
have hemophilia?
3
1. Out of the second generation
siblings, what is the ratio of
hemophiliacs to non-hemophiliacs?
3. How many males in this pedigree have
hemophilia?
2
2:1