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Lesson Sequence Lesson Title 1 What do your genes do / variation 2 3 4 Alleles Genetic Crosses Inherited Disorders 5 Preparing for Assessment / APP 6 7 8 Genetic testing / ethics Cloning Stem Cells 9 Controlled Assessment Practice 10 Exam paper Resources needed: • Comic strip sheet photocopied onto A3 X class set Julien Tamara Jamal Vivian Said Jija Remick Muna Chad Moesha Dylan Jorge Emma Salmon Mohamed James Katia Bukhari Siratillah Mina Denzil Kade Saacid Makayla Shannon Abdul Roberta Rui Dong Board mardi 23 mai 2017 Tuesday, 23 May 2017 martes, 23 de mayo de 2017 Genes and Chromosomes Level Objective Outcome E/D Match offspring to parents using features Describe what a gene is Match up the Simpsons characters with their family, describing how you have done it. Draw a picture to show what a gene is. C/B Explain what a gene is and where in the body they are Label the diagram of a gene and explain its relationship to DNA and chromosomes. A/A* Justify whether genes or upbringing is more important in determining characteristics Define genotype and phenotype. Answered questions on variation in twins. Starter: Complete the genetic jargon worksheet by matching up the keyword to its definition. Keywords Genes, chromosomes, DNA, varaition, inheritance Genetic jargon What has caused these features? To do now: Make a list of features controlled by genes. Make a list of features controlled by the environment. Circle any that appear on both of your lists. Inherited variation is of 2 types: Continuous and discontinuous variation Discontinuous variation has distinct groups. Some examples of discontinuous variation are : tongue rolling Continuous variation doesn't have 2 distinct groups Some examples of continuous variation are : height blood groups heart rate weight finger prints Continuous variation • Sometimes, several genes work together to determine a feature. An example is human eye colour. There is a wide range of possible outcomes and this is called continuous variation. Continuous variation • Continuously varying genetic outcomes may also be affected by environmental factors e.g. milk yield in cows. To do now: Explain, using ideas about continuous variation, why the average human male height in the UK has increased in the last century from 166cm to 175cm. Nature versus nuture The genetic makeup of an individual organism is called the genotype. The physical characteristics that an individual displays are called the phenotype. To do now: Explain why identical twins (who share the same genotype) might have different phenotypes. The disease phenylketonuria (PKU), which is a genetic disorder that causes the amino acid phenylalanine to build up in the blood. Infants are tested for PKU very early because the mental retardation it causes if untreated can be avoided with a special diet. Explain whether the cause and effects of this disease are genetic or environmental. Try to use ideas about genotype and phenotype in your answer. Twin studies Twin studies help us learn how much variation is ______________ and how much is due to the ______________ . Identical twins are genetically ______________ , so any differences between them must be due to the environment. Non-identical twins are genetically ______________ but they grew up in the same surroundings. Similarities between nonidentical twins are probably due to the ______________ . Explain why identical twins share all their genetic information but fraternal twins do not. Where does the information come from? Making a sperm CELL Father Cell How many Chromosomes? 23/05/2017 Father Sperm How many Chromosomes? Making an egg CELL Mother Cell How many Chromosomes? 23/05/2017 Egg Cell How many Chromosomes? Different versions of genes Chromosomes in a pair contain the same type of genes that code for the same characteristics, such as eye colour. Each chromosome in the pair, however, may have a different version of the gene e.g. one for blue eyes and one for brown eyes. allele for brown eyes Each different version of a gene is called an allele. allele for blue eyes • There are two types of alleles (different versions of a gene for the same characteristic). • One is homozygous alleles • The other is heterozygous alleles • Zygous means from the zygote – when the egg and sperm cells meet and join. Homozygous alleles If the alleles for a characteristic in a pair are the same, the organism is said to be homozygous for that characteristic. What colour eyes will these homozygous pairs of alleles produce? allele for brown eyes allele for brown eyes allele for blue eyes allele for blue eyes Heterozygous alleles If the alleles for a characteristic in a pair are different, the organism is said to be heterozygous for that characteristic. What colour eyes will this heterozygous pair of alleles produce? ? allele for brown eyes allele for blue eyes The characteristic expressed by heterozygous alleles will depend on which allele is dominant and which allele is recessive. Task: • What is an allele? • What is a homozygous allele? Can you give an example? • What is a heterozygous allele? Can you give an example? Dominant or recessive? The phenotype for a particular characteristic depends on which allele is dominant and which allele is recessive. Dominant alleles are always expressed in a cell’s phenotype. Only one copy of the dominant allele needs to be inherited in order for it to be expressed. Dominant alleles (e.g. brown eyes) are represented by an upper case letter (e.g. ‘B’). Recessive alleles are only expressed in a cell’s phenotype if two copies of it are present. If only one copy is present, its effect is ‘masked’ by the dominant allele. Recessive alleles (e.g. blue eyes) are represented by a lower case letter (e.g. ‘b’). Task: • What is the difference between a dominant and recessive allele? • Which is the dominant allele in the following pairs: Bb, BB, Hh, rR, rr? How have we done today? Level Objective Outcome E/D Match offspring to parents using features Describe what a gene is Match up the Simpsons characters with their family, describing how you have done it. Draw a picture to show what a gene is. C/B Explain what a gene is and where in the body they are Label the diagram of a gene and explain its relationship to DNA and chromosomes. A/A* Justify whether genes or upbringing is more important in determining characteristics Define genotype and phenotype. Answered questions on variation in twins. Pack away and get ready for the hot seat quiz… • phenotype • Allele • Dominant • Identical twins • Heterozygous allele Which features are inherited?