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Membrane Biophysics and Synaptic Physiology Explanation of cellular and circuit communication using the basic principles of biophysics. Explanation of basic biological phenomenon using physical principles. Membrane Biophysics and Synaptic Physiology •Channel function •Channel function – mitochondrial channels as a model •Transporters •The classical biophysical transporter mechanisms •Unusual mechanisms of transport •Gap Junctions •Voltage •Synaptic gating, chemical gating, and permeation of gap junctions transmission •Calcium dependence of release, two models and mechanisms? •Multivesicular release, when and where? •Synaptic plasticity •Postsynaptic mechanisms, presynaptic mechanisms •Detailed mechanisms •Dendritic and synaptic integration •Direction selectivity as a model Membrane Biophysics and Synaptic Physiology What you need to do: PARTICIPATE – sign up for paper presentations and read all assigned papers and come ready to discuss/question papers. In small groups (1-3 people depending on class size) write a brief proposal to use biophysical or physiological methods to address an important (or interesting) question in neuroscience (see handout for details).