Thomas C. Südhof - Nobel Lecture Slides
... 3. Munc18 binds to SNAREs and is homologous to Unc18 and Sec1p, proteins Munc18 is absolutely essential for vesicle fusion known to be essential for C. elegans movements and yeast secretion by whereas individual SNAREs unknown mechanisms (Südhof laboratory; 1993) are not ...
... 3. Munc18 binds to SNAREs and is homologous to Unc18 and Sec1p, proteins Munc18 is absolutely essential for vesicle fusion known to be essential for C. elegans movements and yeast secretion by whereas individual SNAREs unknown mechanisms (Südhof laboratory; 1993) are not ...
The Formation of Specific Synaptic Connections Between Muscle
... actual formation of specific synaptic connections, is the set of monosynaptic excitatory connections between muscle spindle afferent fibers and motoneurons projecting to limb muscles. These are the connections that underlie the simple myotatic stretch reflex. Intracellular recordings can be made fro ...
... actual formation of specific synaptic connections, is the set of monosynaptic excitatory connections between muscle spindle afferent fibers and motoneurons projecting to limb muscles. These are the connections that underlie the simple myotatic stretch reflex. Intracellular recordings can be made fro ...
Mitochondrial support of persistent presynaptic vesicle mobilization
... and it contained 124 nondocked vesicles and nine docked vesicles. The b3 had 82 nondocked vesicles and two vesicles docked at the PSD which was 4.4 mm from the nearest mitochondrion (b4, nonsyn mito, Dm3, orange line) and 5.3 mm from the end of the axon reconstruction (D3end). Scale cube is 0.5 mm o ...
... and it contained 124 nondocked vesicles and nine docked vesicles. The b3 had 82 nondocked vesicles and two vesicles docked at the PSD which was 4.4 mm from the nearest mitochondrion (b4, nonsyn mito, Dm3, orange line) and 5.3 mm from the end of the axon reconstruction (D3end). Scale cube is 0.5 mm o ...
A tale of two stories: astrocyte regulation of
... astrocytes – the main type of glial cells in the hippocampus and the cortex [16-18] – together with the discovery of two-way astrocyte-neuron communication [19, 20], suggest an active role of these cells in modulation of synaptic transmission and information processing in the brain ...
... astrocytes – the main type of glial cells in the hippocampus and the cortex [16-18] – together with the discovery of two-way astrocyte-neuron communication [19, 20], suggest an active role of these cells in modulation of synaptic transmission and information processing in the brain ...
Functional Microarchitecture of Cat Primary Visual Cortex
... We found that preferred direction, preferred orientation, and orientation tuning width were more clustered than would be expected from a random distribution. However, preferred phase, direction selectivity, relative modulation (F1/DC), and spatial frequency preference and tuning width showed no such ...
... We found that preferred direction, preferred orientation, and orientation tuning width were more clustered than would be expected from a random distribution. However, preferred phase, direction selectivity, relative modulation (F1/DC), and spatial frequency preference and tuning width showed no such ...
Relative Contributions of Specific Activity Histories and
... Indeed, overwhelming experimental evidence supports the idea that synaptic properties are affected by the history of their activation. What is less established and often ignored is the "flip side" of synaptic plasticity: that is, the implicit supposition that synapses, when not driven to change thei ...
... Indeed, overwhelming experimental evidence supports the idea that synaptic properties are affected by the history of their activation. What is less established and often ignored is the "flip side" of synaptic plasticity: that is, the implicit supposition that synapses, when not driven to change thei ...
Document
... processes through the core synaptic algorithm which has strong similarities to the QM wave equation. EvBrain is a form of evolutionary software that can evolve "brainlike" neural networks, such as the network immediately behind the retina. Since November 2008, IBM received a $4.9 million grant from ...
... processes through the core synaptic algorithm which has strong similarities to the QM wave equation. EvBrain is a form of evolutionary software that can evolve "brainlike" neural networks, such as the network immediately behind the retina. Since November 2008, IBM received a $4.9 million grant from ...
Laminar Selectivity of the Cholinergic Suppression of Synaptic
... ACh suppresses excitatory synaptic transmissionin many regions of the cortex, including the piriform cortex (Williams and Constanti, 1988; Hasselmoand Bower, 1992) the dentate gyrus (Yamamoto and Kawai, 1967; Kahle and Cotman, 1989; Burgard and Sarvey, 1990) region CA1 of the hippocampus (Hounsgaard ...
... ACh suppresses excitatory synaptic transmissionin many regions of the cortex, including the piriform cortex (Williams and Constanti, 1988; Hasselmoand Bower, 1992) the dentate gyrus (Yamamoto and Kawai, 1967; Kahle and Cotman, 1989; Burgard and Sarvey, 1990) region CA1 of the hippocampus (Hounsgaard ...
Filamentous contacts: the ultrastructure and three
... &p.1:Abstract. Filamentous contacts are non-synaptic interneuronal junctions characteristic of thalamic relay nuclei. Symmetrical filamentous contacts occur between two dendrites, two somata or a dendrite and a soma; asymmetrical filamentous contacts occur between axon terminals and dendrites, or oc ...
... &p.1:Abstract. Filamentous contacts are non-synaptic interneuronal junctions characteristic of thalamic relay nuclei. Symmetrical filamentous contacts occur between two dendrites, two somata or a dendrite and a soma; asymmetrical filamentous contacts occur between axon terminals and dendrites, or oc ...
Fluctuations in Perceptual Decisions Panagiota Theodoni
... realistic attractor network, by consistently reducing it to a fourvariable rate- based model, and by extracting analytical expressions for second- order statistics. We considered human behavioral and macaque neurophysiological data collected when subjects were confronting with such ambiguities. Our ...
... realistic attractor network, by consistently reducing it to a fourvariable rate- based model, and by extracting analytical expressions for second- order statistics. We considered human behavioral and macaque neurophysiological data collected when subjects were confronting with such ambiguities. Our ...
mGluR-dependent persistent firing in entorhinal cortex layer III neurons SYNAPTIC MECHANISMS Motoharu Yoshida,
... suggest an involvement of metabotropic glutamate receptors (mGluRs) in persistent firing. Using whole-cell patch-recording techniques in a rat entorhinal cortex (EC) slice preparation, we tested whether EC layer III neurons display persistent firing due to mGluR activation, independently of choliner ...
... suggest an involvement of metabotropic glutamate receptors (mGluRs) in persistent firing. Using whole-cell patch-recording techniques in a rat entorhinal cortex (EC) slice preparation, we tested whether EC layer III neurons display persistent firing due to mGluR activation, independently of choliner ...
Protracted Synaptogenesis after Activity
... for 4 h on a shaker. Slices were removed from the coverslip using a paint brush, transferred though an ascending gradient of PB-based sucrose solutions, and then subjected to a freeze–thaw cycle using liquid nitrogen. The biocytin label was revealed using a Vectastein Elite ABC kit (Axxora, Grünber ...
... for 4 h on a shaker. Slices were removed from the coverslip using a paint brush, transferred though an ascending gradient of PB-based sucrose solutions, and then subjected to a freeze–thaw cycle using liquid nitrogen. The biocytin label was revealed using a Vectastein Elite ABC kit (Axxora, Grünber ...
The Time Course and Amplitude of EPSPs Evoked at Synapses
... while evoking unitary EPSPs in the same CA1 cell. The CA3 neuron was activated by a depolarizing current pulse (Fig. 2E). Examples of individual responses in the CA 1 neuron are shown in Figure 2, FI-F4, and the average of 1780 individual records is shown in Figure 2G. The averaging procedure includ ...
... while evoking unitary EPSPs in the same CA1 cell. The CA3 neuron was activated by a depolarizing current pulse (Fig. 2E). Examples of individual responses in the CA 1 neuron are shown in Figure 2, FI-F4, and the average of 1780 individual records is shown in Figure 2G. The averaging procedure includ ...
view - E-LIB Bremen - Universität Bremen
... likely that they will fire together in the future, even if only a subset of the cell assembly gets excited by an incomplete stimulus. For example, if we observe a bird singing a characteristic song, we will later be able to identify the type of bird if we only hear its song. Around 20 years after Heb ...
... likely that they will fire together in the future, even if only a subset of the cell assembly gets excited by an incomplete stimulus. For example, if we observe a bird singing a characteristic song, we will later be able to identify the type of bird if we only hear its song. Around 20 years after Heb ...
Structure of Receptive Fields in Area 3b of Primary Somatosensory
... determines the neuronal response to complex spatial patterns scanned across the skin. Several lines of evidence suggest that the neural signals that underlie the perception of tactile form and texture on the glabrous skin of the primate fingerpad are conveyed initially by the population of slowly ad ...
... determines the neuronal response to complex spatial patterns scanned across the skin. Several lines of evidence suggest that the neural signals that underlie the perception of tactile form and texture on the glabrous skin of the primate fingerpad are conveyed initially by the population of slowly ad ...
Glia-Derived D-Serine Controls NMDA Receptor Activity and
... from that observed in DAAO-treated virgin slices (p > 0.05; Figures 2A and 2B). Since AMPAR-mediated responses in SON neurons are not altered by lactation (Oliet et al., 2001; Stern et al., 2000), such a change in the ratio implies a change in NMDAR-mediated EPSCs. Because different NR2 subunits con ...
... from that observed in DAAO-treated virgin slices (p > 0.05; Figures 2A and 2B). Since AMPAR-mediated responses in SON neurons are not altered by lactation (Oliet et al., 2001; Stern et al., 2000), such a change in the ratio implies a change in NMDAR-mediated EPSCs. Because different NR2 subunits con ...
Learning to classify complex patterns using a VLSI network of
... as problems of noisy, unmatched elementary devices. Although the reasons for the superiority of the nervous system in the real world are not completely understood, it is obvious that the main methods of neural computation in biology are very different from those of modern digital computers. In the b ...
... as problems of noisy, unmatched elementary devices. Although the reasons for the superiority of the nervous system in the real world are not completely understood, it is obvious that the main methods of neural computation in biology are very different from those of modern digital computers. In the b ...
- [email protected]
... they begin to form relatively crude functional connections. These initial connections undergo substantial synaptic rearrangements during development, which result in precise, mature neuronal circuitry. In many parts of the nervous system, elimination of exuberant inputs is a key process of developme ...
... they begin to form relatively crude functional connections. These initial connections undergo substantial synaptic rearrangements during development, which result in precise, mature neuronal circuitry. In many parts of the nervous system, elimination of exuberant inputs is a key process of developme ...
Soghomonian J.J., Sethares C., and Peters, A
... Author Manuscript Neuroscience. Author manuscript; available in PMC 2011 June 16. ...
... Author Manuscript Neuroscience. Author manuscript; available in PMC 2011 June 16. ...
Disentanglement of local field potential sources by independent
... Abstract The spontaneous activity of working neurons yields synaptic currents that mix up in the volume conductor. This activity is picked up by intracerebral recording electrodes as local field potentials (LFPs), but their separation into original informative sources is an unresolved problem. Assum ...
... Abstract The spontaneous activity of working neurons yields synaptic currents that mix up in the volume conductor. This activity is picked up by intracerebral recording electrodes as local field potentials (LFPs), but their separation into original informative sources is an unresolved problem. Assum ...
Inhibitory Plasticity Balances Excitation and Inhibition in Sensory
... processing in cortical networks, it is not understood by which mechanisms this balance is established and maintained during ongoing sensory experiences. Inspired by recent experimental results (7), we investigated the hypothesis that synaptic plasticity at inhibitory synapses plays a central role in ...
... processing in cortical networks, it is not understood by which mechanisms this balance is established and maintained during ongoing sensory experiences. Inspired by recent experimental results (7), we investigated the hypothesis that synaptic plasticity at inhibitory synapses plays a central role in ...
DCN principal cells respond to spectral edges, which requires additional inhibitory effects in DCN
... valid for high spontaneous rate fibers, simulations were restricted to low sound levels in the middle of the dynamic range of these fibers for broadband stimuli, at approximate pass-band levels of 0 dB. This was necessary because both real (Hellstrom, 1998) and simulated high spontaneous rate fibers ...
... valid for high spontaneous rate fibers, simulations were restricted to low sound levels in the middle of the dynamic range of these fibers for broadband stimuli, at approximate pass-band levels of 0 dB. This was necessary because both real (Hellstrom, 1998) and simulated high spontaneous rate fibers ...
Down - 서울대 : Biointelligence lab
... all presynaptic spike trains) in simulation of an IF-neuron with 1000 input channels. The spike trains that lead to the results shown by stars were generated with each weight value fixed to value 0.015. The cross-correlations are consistent with zero when considered within the variance indicated by ...
... all presynaptic spike trains) in simulation of an IF-neuron with 1000 input channels. The spike trains that lead to the results shown by stars were generated with each weight value fixed to value 0.015. The cross-correlations are consistent with zero when considered within the variance indicated by ...
Changes of Synaptic Density in the Primary Visual Cortex of the
... We also compared the three different calibration grids utilized throughout this entire study by making a series of electron micrographs on the same day and found no significant deformation between the oldest and the newest ones. No attempt was made to estimate the degree of shrinkage from exposure t ...
... We also compared the three different calibration grids utilized throughout this entire study by making a series of electron micrographs on the same day and found no significant deformation between the oldest and the newest ones. No attempt was made to estimate the degree of shrinkage from exposure t ...