Excitatory and Inhibitory Vestibular Pathways to the Extraocular
... distribution of gap junctions (present study). Data herein also will show that electrotonic coupling is present in all of the semicircular canal pathways that produce compensatory, i.e., not rapid, eye movements. Hence one goal was to achieve a consensus with prior work by employing a broad approach ...
... distribution of gap junctions (present study). Data herein also will show that electrotonic coupling is present in all of the semicircular canal pathways that produce compensatory, i.e., not rapid, eye movements. Hence one goal was to achieve a consensus with prior work by employing a broad approach ...
Focal local field potential (LFP) signature of the single
... to investigate neural network activity. To probe monosynaptic thalamic activation of cortical postsynaptic target cells, so called spike-trigger-averaged LFP (stLFP) signatures have been measured. In these experiments the cortical LFP is measured by means of multielectrodes covering several cortical ...
... to investigate neural network activity. To probe monosynaptic thalamic activation of cortical postsynaptic target cells, so called spike-trigger-averaged LFP (stLFP) signatures have been measured. In these experiments the cortical LFP is measured by means of multielectrodes covering several cortical ...
Focal local field potential (LFP) signature of the single
... to investigate neural network activity. To probe monosynaptic thalamic activation of cortical postsynaptic target cells, so called spike-trigger-averaged LFP (stLFP) signatures have been measured. In these experiments the cortical LFP is measured by means of multielectrodes covering several cortical ...
... to investigate neural network activity. To probe monosynaptic thalamic activation of cortical postsynaptic target cells, so called spike-trigger-averaged LFP (stLFP) signatures have been measured. In these experiments the cortical LFP is measured by means of multielectrodes covering several cortical ...
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... spikes propagate, postsynaptic potentials (PSPs) in the B8 neurons are not recorded. In other systems, synaptic transmission generally occurs when spikes are evoked relatively close to resting membrane potential. Taken together, previous data and these results indicate that our preparation is unique ...
... spikes propagate, postsynaptic potentials (PSPs) in the B8 neurons are not recorded. In other systems, synaptic transmission generally occurs when spikes are evoked relatively close to resting membrane potential. Taken together, previous data and these results indicate that our preparation is unique ...
Gene Dosage in the Dysbindin Schizophrenia Susceptibility
... Author contributions: A.P.M., M.K.S., D.K.D., K.V., M.R., S.S., and V.F. designed research; A.P.M., M.K.S., M.R., and S.S. performed research; W.M., D.K.D., K.V., and M.R. contributed unpublished reagents/analytic tools; A.P.M., M.K.S., K.V., M.R., S.S., and V.F. analyzed data; A.P.M., M.R., S.S., a ...
... Author contributions: A.P.M., M.K.S., D.K.D., K.V., M.R., S.S., and V.F. designed research; A.P.M., M.K.S., M.R., and S.S. performed research; W.M., D.K.D., K.V., and M.R. contributed unpublished reagents/analytic tools; A.P.M., M.K.S., K.V., M.R., S.S., and V.F. analyzed data; A.P.M., M.R., S.S., a ...
The Matrix Protein Hikaru genki Localizes to Cholinergic Synaptic
... line; when the center of each signal was focused, the D␣7-GFP signals were closely associated with Hig (Fig. 1F ). Structured illumination microscopy also revealed fine images of a single synapse in which Hig was present between the presynaptic marker Brp and the postsynaptic marker D␣7-GFP, indicat ...
... line; when the center of each signal was focused, the D␣7-GFP signals were closely associated with Hig (Fig. 1F ). Structured illumination microscopy also revealed fine images of a single synapse in which Hig was present between the presynaptic marker Brp and the postsynaptic marker D␣7-GFP, indicat ...
ROLE OF EARLY ACOUSTIC EXPERIENCE IN DEVELOPMENT OF THE RAT by
... Neural plasticity is the ability of neurons and their functional connections to undergo changes in their anatomical, chemical, and physiological properties (Kolb & Whishaw, 1998). Such changes occur at all levels in the central nervous system, from molecular and synaptic modifications that underlie ...
... Neural plasticity is the ability of neurons and their functional connections to undergo changes in their anatomical, chemical, and physiological properties (Kolb & Whishaw, 1998). Such changes occur at all levels in the central nervous system, from molecular and synaptic modifications that underlie ...
Fut u re N
... the lateral entorhinal cortex [4,5]. Exciting recent studies have shown that tau pathology can spread between structures, but even these studies do not yet address why neurofibrillary tangles appear to spread along specific pathways, but not others [6,7]. In this article, we describe a hypothesis th ...
... the lateral entorhinal cortex [4,5]. Exciting recent studies have shown that tau pathology can spread between structures, but even these studies do not yet address why neurofibrillary tangles appear to spread along specific pathways, but not others [6,7]. In this article, we describe a hypothesis th ...
Sensory Adaptation and Short Term Plasticity as Bayesian
... because presynaptic neurons are highly excitable. In order to adapt in a way that preserves sensory information, the nervous system needs to resolve this ambiguity. Specifically, the nervous system can use information about the way excitability typically changes over time and information about the w ...
... because presynaptic neurons are highly excitable. In order to adapt in a way that preserves sensory information, the nervous system needs to resolve this ambiguity. Specifically, the nervous system can use information about the way excitability typically changes over time and information about the w ...
166 - UCSF Physiology - University of California, San Francisco
... Integrins are a large family of cell adhesion receptors involved in a variety of cellular functions. To study their roles at central synapses, we used two cre recombinase lines to delete the Itgb1 1 integrin gene in forebrain excitatory neurons at different developmental stages. Removal of the 1 i ...
... Integrins are a large family of cell adhesion receptors involved in a variety of cellular functions. To study their roles at central synapses, we used two cre recombinase lines to delete the Itgb1 1 integrin gene in forebrain excitatory neurons at different developmental stages. Removal of the 1 i ...
Retrograde Signaling in the Development and Modification of
... can regulate the growth and projection pattern of other processes of the same neuron (124, 129) and change the global membrane excitability or transmitter sensitivity of the neuron (202). The target cell innervated by the axonal terminal (226, 297) regulates even synaptic connections formed on the p ...
... can regulate the growth and projection pattern of other processes of the same neuron (124, 129) and change the global membrane excitability or transmitter sensitivity of the neuron (202). The target cell innervated by the axonal terminal (226, 297) regulates even synaptic connections formed on the p ...
with task performance neural responses and determining their
... The methods we describe here are useful for analyzing the neural data from experiments in which experimental conditions are combinations of multiple stimulus parameters (e.g., sensory stimuli combined with different task instructions). Additionally, they can be applied to both parametric variation ( ...
... The methods we describe here are useful for analyzing the neural data from experiments in which experimental conditions are combinations of multiple stimulus parameters (e.g., sensory stimuli combined with different task instructions). Additionally, they can be applied to both parametric variation ( ...
Resonance Effect for Neural Spike Time Reliability
... van Steveninck et al. 1997). These results suggest that the intrinsic noise in the spike-generating mechanism is low relative to the intensity of the fluctuating input currents. In interpreting these results, an important consideration is the magnitude of the fluctuations in the input relative to th ...
... van Steveninck et al. 1997). These results suggest that the intrinsic noise in the spike-generating mechanism is low relative to the intensity of the fluctuating input currents. In interpreting these results, an important consideration is the magnitude of the fluctuations in the input relative to th ...
Information Processing at the Calyx of Held Under Natural Conditions
... results in the context of a mathematical vesicle-release model. One of the hallmarks of auditory neurons in vivo is spontaneous activity that occurs even in the absence of any sensory stimuli. Sound evoked bursts of discharges are thus embedded within this background of random firing. The calyx of H ...
... results in the context of a mathematical vesicle-release model. One of the hallmarks of auditory neurons in vivo is spontaneous activity that occurs even in the absence of any sensory stimuli. Sound evoked bursts of discharges are thus embedded within this background of random firing. The calyx of H ...
Neurotransmitter Release
... only in the 20th century. It was embedded in a larger debate of whether neurons form a “reticular” network of connected cells, or a network of cells whose connections are discontinuous (the so-called neuron theory). Like with everything else in neuroscience, Ramón y Cajal is usually credited with t ...
... only in the 20th century. It was embedded in a larger debate of whether neurons form a “reticular” network of connected cells, or a network of cells whose connections are discontinuous (the so-called neuron theory). Like with everything else in neuroscience, Ramón y Cajal is usually credited with t ...
Bayesian Spiking Neurons II: Learning
... 1984; Bishop, 1995; Bell & Sejnowski, 1995) and have strong experimental support (Bliss & Collingridge, 1993). However, recent evidence suggests that synaptic long-term plasticity rules depend not only on the average coactivation of the pre- and postsynaptic inputs, but also on the exact temporal st ...
... 1984; Bishop, 1995; Bell & Sejnowski, 1995) and have strong experimental support (Bliss & Collingridge, 1993). However, recent evidence suggests that synaptic long-term plasticity rules depend not only on the average coactivation of the pre- and postsynaptic inputs, but also on the exact temporal st ...
Clarinet (CLA-‐1), a novel active zone protein required for synaptic
... synaptic vesicles adjacent to the dense projection and an increased number of docked vesicles. Cla-‐1 ...
... synaptic vesicles adjacent to the dense projection and an increased number of docked vesicles. Cla-‐1 ...
Clarinet (CLA-‐1), a novel active zone protein required for
... synaptic vesicles adjacent to the dense projection and an increased number of docked vesicles. Cla-‐1 ...
... synaptic vesicles adjacent to the dense projection and an increased number of docked vesicles. Cla-‐1 ...
Applying Transcranial Alternating Current Stimulation to the Study of Spike Timing Dependent Plasticity in Neural Networks
... physiologically accurate than the similar, but more complex, Hodgkin Huxley model, the FN model’s simplicity to implement and accurate mimicking of general neural spiking behavior make it an ideal first choice for the purposes of generating a neural micro-network. The specific FN model used here was ...
... physiologically accurate than the similar, but more complex, Hodgkin Huxley model, the FN model’s simplicity to implement and accurate mimicking of general neural spiking behavior make it an ideal first choice for the purposes of generating a neural micro-network. The specific FN model used here was ...
Perception Spike Timing-Dependent Plasticity: From Synapse to
... described by a small number of parameters, and the dependence of synaptic modification on these parameters (e.g., pre/post spike interval) can be easily determined. For neural circuits in vivo, however, spiking in both preand postsynaptic cells is likely to be irregular (98), with occasional high-fr ...
... described by a small number of parameters, and the dependence of synaptic modification on these parameters (e.g., pre/post spike interval) can be easily determined. For neural circuits in vivo, however, spiking in both preand postsynaptic cells is likely to be irregular (98), with occasional high-fr ...
Spike Timing-Dependent Plasticity: From Synapse to Perception
... individual pyramidal neurons with enhanced processing capacity (44, 94), the computational power can only be harvested if the inputs carrying different signals are segregated into distinct regions (8, 72). In fact, the importance of domain-specific inputs has been well recognized for inhibitory inte ...
... individual pyramidal neurons with enhanced processing capacity (44, 94), the computational power can only be harvested if the inputs carrying different signals are segregated into distinct regions (8, 72). In fact, the importance of domain-specific inputs has been well recognized for inhibitory inte ...
DECODING NEURONAL FIRING AND MODELING NEURAL
... over an extended period, the final form of the kernel reflects both the firing properties of the neuron and the statistics of the input data stream. Generating a direct estimate of the stimulus signal, xest (t) = r(t), is not the only thing that can be done with a linear filter. Other measures of th ...
... over an extended period, the final form of the kernel reflects both the firing properties of the neuron and the statistics of the input data stream. Generating a direct estimate of the stimulus signal, xest (t) = r(t), is not the only thing that can be done with a linear filter. Other measures of th ...
The Dialectics of Hebb and Homeostasis within
... compensation, is still not entirely clear. On a theoretical level, the existence of “firing rate set points” in neocortical neurons provides a means for circuits to self-tune excitability over long time-scales to prevent the development of hypo or hyperexcitable states (Turrigiano and Nelson, 2004). ...
... compensation, is still not entirely clear. On a theoretical level, the existence of “firing rate set points” in neocortical neurons provides a means for circuits to self-tune excitability over long time-scales to prevent the development of hypo or hyperexcitable states (Turrigiano and Nelson, 2004). ...
Ectopic sensory neurons in mutant cockroaches
... anatomical difference between the two afferents is their appearance in transverse section: M forms a characteristic circum-glomerular arborization, and L occupies mainly the ventro-lateral margins of the glomerulus. Neither axon forms extensive branches within the core of the glomerulus, apart from ...
... anatomical difference between the two afferents is their appearance in transverse section: M forms a characteristic circum-glomerular arborization, and L occupies mainly the ventro-lateral margins of the glomerulus. Neither axon forms extensive branches within the core of the glomerulus, apart from ...
Synaptic Depression and the Temporal Response Characteristics of
... highly simplified, the synaptic dynamics is modeled quite accurately using a mathematical description that fits experimental data (Abbott et al., 1997; Varela et al., 1997). Although a number of mechanisms may contribute to temporal nonlinearities in cortical responses, we focus rather exclusively o ...
... highly simplified, the synaptic dynamics is modeled quite accurately using a mathematical description that fits experimental data (Abbott et al., 1997; Varela et al., 1997). Although a number of mechanisms may contribute to temporal nonlinearities in cortical responses, we focus rather exclusively o ...