Download Victor YU - National University of Singapore

Victor Chun-Kong Yu,
B.Sc. (Hons) Pharm., Houston
Ph.D., Pharm. Chem., University of California, San Francisco
Associate Professor
Department of Pharmacy
National University of Singapore
S15-L5-PI-02, Science Drive 2
Phone: (65) 6516-8216
E-mail: [email protected]
RESEARCH INTERESTS
Apoptosis Signaling Mechanisms in Mitochondria
Bcl-2 family of proteins
Enteroinvasive Bacterial Pathogens
Ubiquitin-Proteasome System
Chemical Biology
REPRESENTATIVE PUBLICATIONS
(1) V.C. Yu, C. Delsert, B. Andersen, J.M. Holloway, O.V. Devary, A.M. Näär, S.Y. Kim, J.M. Boutin, C.K. Glass
and M.G. Rosenfeld. RXR: A Coregulator that Enhances Binding of Retinoic Acid, Thyroid Hormone, and
Vitamin D Receptors to Their Cognate Response Elements. Cell, 67, 1251-66, 1991.
(2) A.M. Näär, J.M. Boutin, S.M. Lipkin, V.C. Yu, J.M. Holloway, C.K. Glass and M.G. Rosenfeld. The
Orientation and Spacing of Core DNA-Binding Motifs Dictate Selective Transcriptional Responses to Three
Nuclear Receptors. Cell, 65, 1267-79, 1991.
(3) S.J. Rhoades, R. Chen, G.E. Dimattia, K.M. Scully, K.A. Kalla, S.C. Lin, V.C. Yu and M.G. Rosenfeld. A
Tissue-Specific Enhancer Confers Pit-1 Dependent Morphogen Inducibility and Autoregulation Upon the Pit-1
Genes. Genes & Development, 7, 913-932, 1993.
(4) R. Kurokawa, V.C. Yu, A. Näär, S. Kyakumoto, Z. Han, S. Silverman, M.G. Rosenfeld and C.K. Glass.
Differential Orientations of the C-terminal Dimerization Interface Determine Binding Site Selection by Nuclear
Receptor Heterodimers. Genes & Development, 7, 1423-1435, 1993.
(5) K.O. Tan, K.M.L. Tan, S.L. Chan, K.S.Y. Yee, M. Bevort, K.C. Ang and V.C. Yu. MAP-1, a novel
pro-apoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology
domains. J. Biol. Chem. 276: 2802-2807, 2001.
(6) S. L. Chan, M.C. Lee, K.O. Tan, L.K. Yang, A.S.Y. Lee, H. Flotow, N. Y. Fu, M.S. Butler, D.D.
Soejarto, A.D. Buss and V.C. Yu Identification of chelerythrine as an inhibitor of BclXL function, J. Biol.
Chem. (Accelerated Publication), 278: 20453-20456, 2003
(7) B.T. Chua, C. Volbracht, K.O. Tan, R. Li, and V.C. Yu and P. Li Mitochondrial translocation to
cofilin is an early step in apoptosis induction. Nature Cell Biology, 12: 1083-1089, 2003
(8) S. Baksh, S. Tommasi, S. Fenton, V.C. Yu, L.M. Martins, G.P. Pfeifer, F. Latiff, J. Downward and
B.G. Neel The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational
change and cell death, Molecular Cell 18: 637-650, 2005
(9) K.O. Tan, N.Y. Fu, S.K. Sukumaran, S.L. Chan, K.L. Poon, K.J. Hian, B.S. Chen and V.C. Yu MAP1 is a mitochondrial effector of Bax, Proc. Natl. Acad. Sci. USA, 102: 14623-14688, 2005
(10) N.Y. Fu, S.K. Sukumaran and V.C. Yu Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic
stimuli promotes Bax function in mitochondria, Track II, Proc. Natl. Acad. Sci. USA, 104: 10051-10056, 2007.
(11) N.Y. Fu, S.K. Sukumaran and V.C. YU Baxβ: a constitutively active human Bax isoform that is under tight
regulatory control by the proteasomal degradation mechanism, Molecular Cell, 33: 15-29, 2009.
(12) S.K. Sukumaran, N.Y. Fu, B.T. Chua, K.F. Wan, S.S. Lee and V.C. YU A soluble form of the pilus protein
FimA targets the VDAC-hexokinase complex at mitochondria to inhibit host cell apoptosis, Molecular Cell,
37: 768-783, 2010
Updated on 04/13/10
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