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Victor Chun-Kong Yu, B.Sc. (Hons) Pharm., Houston Ph.D., Pharm. Chem., University of California, San Francisco Associate Professor Department of Pharmacy National University of Singapore S15-L5-PI-02, Science Drive 2 Phone: (65) 6516-8216 E-mail: [email protected] RESEARCH INTERESTS Apoptosis Signaling Mechanisms in Mitochondria Bcl-2 family of proteins Enteroinvasive Bacterial Pathogens Ubiquitin-Proteasome System Chemical Biology REPRESENTATIVE PUBLICATIONS (1) V.C. Yu, C. Delsert, B. Andersen, J.M. Holloway, O.V. Devary, A.M. Näär, S.Y. Kim, J.M. Boutin, C.K. Glass and M.G. Rosenfeld. RXR: A Coregulator that Enhances Binding of Retinoic Acid, Thyroid Hormone, and Vitamin D Receptors to Their Cognate Response Elements. Cell, 67, 1251-66, 1991. (2) A.M. Näär, J.M. Boutin, S.M. Lipkin, V.C. Yu, J.M. Holloway, C.K. Glass and M.G. Rosenfeld. The Orientation and Spacing of Core DNA-Binding Motifs Dictate Selective Transcriptional Responses to Three Nuclear Receptors. Cell, 65, 1267-79, 1991. (3) S.J. Rhoades, R. Chen, G.E. Dimattia, K.M. Scully, K.A. Kalla, S.C. Lin, V.C. Yu and M.G. Rosenfeld. A Tissue-Specific Enhancer Confers Pit-1 Dependent Morphogen Inducibility and Autoregulation Upon the Pit-1 Genes. Genes & Development, 7, 913-932, 1993. (4) R. Kurokawa, V.C. Yu, A. Näär, S. Kyakumoto, Z. Han, S. Silverman, M.G. Rosenfeld and C.K. Glass. Differential Orientations of the C-terminal Dimerization Interface Determine Binding Site Selection by Nuclear Receptor Heterodimers. Genes & Development, 7, 1423-1435, 1993. (5) K.O. Tan, K.M.L. Tan, S.L. Chan, K.S.Y. Yee, M. Bevort, K.C. Ang and V.C. Yu. MAP-1, a novel pro-apoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains. J. Biol. Chem. 276: 2802-2807, 2001. (6) S. L. Chan, M.C. Lee, K.O. Tan, L.K. Yang, A.S.Y. Lee, H. Flotow, N. Y. Fu, M.S. Butler, D.D. Soejarto, A.D. Buss and V.C. Yu Identification of chelerythrine as an inhibitor of BclXL function, J. Biol. Chem. (Accelerated Publication), 278: 20453-20456, 2003 (7) B.T. Chua, C. Volbracht, K.O. Tan, R. Li, and V.C. Yu and P. Li Mitochondrial translocation to cofilin is an early step in apoptosis induction. Nature Cell Biology, 12: 1083-1089, 2003 (8) S. Baksh, S. Tommasi, S. Fenton, V.C. Yu, L.M. Martins, G.P. Pfeifer, F. Latiff, J. Downward and B.G. Neel The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death, Molecular Cell 18: 637-650, 2005 (9) K.O. Tan, N.Y. Fu, S.K. Sukumaran, S.L. Chan, K.L. Poon, K.J. Hian, B.S. Chen and V.C. Yu MAP1 is a mitochondrial effector of Bax, Proc. Natl. Acad. Sci. USA, 102: 14623-14688, 2005 (10) N.Y. Fu, S.K. Sukumaran and V.C. Yu Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria, Track II, Proc. Natl. Acad. Sci. USA, 104: 10051-10056, 2007. (11) N.Y. Fu, S.K. Sukumaran and V.C. YU Baxβ: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism, Molecular Cell, 33: 15-29, 2009. (12) S.K. Sukumaran, N.Y. Fu, B.T. Chua, K.F. Wan, S.S. Lee and V.C. YU A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to inhibit host cell apoptosis, Molecular Cell, 37: 768-783, 2010 Updated on 04/13/10 1