Download Molecular Biology - Bard Early Colleges

Immunology
(SBS11U1I—3 credits)
Siska Brutsaert PhD [email protected] (212) 995-8479 ext 4072
Monday and Wednesday 3rd period (10:50-11:40 am)
Lab Thusday 2nd and 3rd period
Office Hours- 5th period or by appointment
room 409
lab room 301
This course will cover fundamental principles in molecular biology by studying the body’s defense against
infections. Biochemical processes such as gene regulation, RNA and protein synthesis, and signal transduction
will be studied within the context of the immune system. Cellular processes including signal transduction, cell
division and differentiation, clonal selection, apoptosis and survival will be learned as it relates to immune cells
and immune responses. Students will critically evaluate current scientific literature in the field of immunology,
learn about molecular biology techniques and experimentation, perform basic molecular biology techniques in
the lab, gain awareness of bioethical issues in the field of immunology, and discuss case studies in immunology.
Units of Study:
Unit 1- Cells of the Immune System and Innate Immunity- The first unit will discuss the cells of the immune
system and cellular processes relevant to immune cell function such as signal transduction, gene regulation,
phagocytosis, endocytosis, and clonal selection. Students will also learn about the innate immune system, and
the immune system of primitive organisms.
Unit 2- Molecules of the Immune System- The second unit will explore molecular interactions fundamental to
immune cell function. Topics will include receptor ligand interactions, antigen processing and presentation, and
immunoglobulin and T cell receptor gene rearrangement.
Unit 3- Adaptive Immunity- Unit 3 will cover T- cell mediated immunity, humoral immunity, MHCI and
MHCII responses and immunological memory.
Unit 4- Immune System in Health and Disease- Topics discussed in this unit will include: evasion and
subversion of the immune system by pathogens, allergy and autoimmunity.
LAB- Immunologist’s tool box- The theme for the lab portion of this course is the Immunologist’s tool box.
Students will learn about current techniques in the field of immunology research and clinical assays in immune
health.
Sequence of topics:
Week of Immunology Topic
Writing and Thinking9/8
Overview of the Immune System
9/15
Cells of the Immune System
Elements of Innate and Acquired
9/22
Immunity
Cellular Processes in hematopoetic
9/29
cells
Cellular Processes in hematopoetic
10/6
cells
Innate immunity
10/13
Exam I
10/20
Bard High School Early College
[email protected]
Lab / Workshop
Bioethics I
Probioics
Case Study
Edward Jenner
Rosh Hashanah
Severe Congenital Neutropenia
Blood Typing
Hemolytic Disease of the Newborn
Arendt Center Trip
Immunology
Fall 2014
10/28
Antibody structure and function
ELISA
11/6
11/13
Genetic Basis of Antibody Structure
B lymphocyte biology
Protein Extraction
SDS-PAGE
11/20
11/27
12/3
12/10
Exam II
Major Histocompatibility
Antigen Presentation to T-cells
Activation and Function of B and T
cells
Immunological Memory
Exam III
Immune System in Health and Disease
Immune System in Health and Disease
12/17
12/22
1/5
1/12
Acquired Immune Deficiency
Syndrome
Common Variable
Immunodeficiency
Ataxia Telangiectasia
Immunoblotting
Immunoblotting
X-linked Agammaglobulinemia
Final Projects
Final Projects
The grade for this course will be based on:
1) Written assignments (30%)
2) Midterms and quizzes (30%)
3) Final Project and Final Exam (30%)
4) Class and laboratory participation (10%)
Final Project- The final project will contribute to 50% of the final exam grade. The final project will include a
written component as well as an oral presentation. For this project, students will be required to analyze a
primary research article and present the data in the article. More details about the final project will be
distributed in November.
Texts:
 Case Studies in Immunology: A Clinical Companion 6th Ed.- Raif Geha and Luigi Notarangelo
 Janeway’s Immunobiology 7th Ed.- Murphy, Travers, and Walport
 Other primary sources and readings
Requirements
Materials
 three ring binder with dividers, loose leaf paper, pens/pencils, access to the internet
Come to Class Prepared
 Read the text and participate in online activities
 Complete pre-lab activity prior to labs
 Turn in assignments on time. Late assignments will loose 10% for each day it is late.
 If you are ill, your work is due the day you get back.
 Students are expected to treat each other with respect in both words and actions.
 Students are discouraged from eating in class
Cell Phone Policy:
Cell phones MUST BE TURNED OFF when students are in the classroom. If a cell phone goes off
during class, it will be taken from the student and given to the Principal.
Absences and Tardies
Bard High School Early College
[email protected]
Immunology
Fall 2014
 Please be in your seat and ready to work when class starts.
 Students must make up all work missed during absences. It is the student’s responsibility to get
notes, handouts, assignments and other information that were missed during absences.
 Assignments are due the day you return from an absence. Arrangements to make up tests must be
made for within 3 days of return from an absence.
 If a student misses more than 1 lab, for each unexcused lab absence, 5% will be deducted from the
final grade for the course.
Academic Integrity- Please see the BHSEC Academic Integrity Handbook.
 All work (homework, quizzes, tests, papers, projects, labs, etc.) must be the student’s own work.
 Cheating includes, but is not limited to:
o submitting work copied from a friend or an outside source (without attribution)
o giving work to a friend or giving/receiving excessive assistance from someone
o accepting or giving help during a test or quiz.
o Using notes without expressed permission of the teacher
 Plagiarism, a form of cheating, involves presenting someone else's ideas or words, whether
deliberate or inadvertent, without giving credit!
 Any work that is not the student’s own work will get no credit.
Bard High School Early College
[email protected]
Immunology
Fall 2014