Download Topic: DISORDERS OF PROTEIN METABOLISM. GOUT

Topic: DISORDERS OF PROTEIN
METABOLISM. GOUT
Aim of the lesson: to study disorders of protein metabolism, mechanisms of protein
insufficiency and gout development and their complications.
QUESTIONS:
1. Biological role of proteins, peptides and amino acids.
Consequences of amino acid insufficiency.
2. Fasting. Types of fasting. Metabolic and functional disturbances in fasting.
3. Causes of protein insufficiency. Protein-calorie malnutrition. Particularities in children
(Kwashiorkor).
4. Causes and consequences of protein digestion disturbances. Symptoms. Celiac-sprue.
5. Causes and consequences of intermediary amino acid metabolism.
6. Pathology of plasma protein composition. Disproteinemia types and their features.
7. Types of residual plasma nitrogen level increasing. Mechanisms of their development.
8. Gout. Pathogenesis of symptoms.
LITERATURE:
1. Lecture material.
2. Copstead L.E., Banasik J.L. Pathophysiology. – 4th ed. – Saunders.: Elsivierm, 2010. – 1363 p.
3. V. Kumar, AK Abbas, SN Fauso. Pathologic basis of disease, 7 th edition, 2007 – 1525p
4. Harsh Mohan-Textbook of pathology – 2004
Tests
1. Disorder of tyrosine methabolism leads to:
a) tyrosinosis
b) alkaptonuria
c) albinism
d) phenylketonuria
2. The causes of positive nitrogen balance are:
a) growth
b) pregnancy
c) fever
d) burn
3. What substances are inhibitory transmitters?
a) aspartate
b) glutamate
c) glycine
d) Gamma-aminobutiric acid (GABA)
4. What substances are excitatory neurotransmitters?
a) aspartate
b) glutamate
c) glycine
d) gamma-aminobutiric acid (GABA)
5. Increased basal metabolic rate is the result of increased level of:
a) adrenocorticotropic hormone (ACTH)
b) insuline
c) parathormone
d) thyroxin
6.
a)
b)
c)
d)
Which protein fraction prevails in blood?
α1-globuline
β-globulin
albumen
α2-globuline
7.
a)
b)
c)
Which protein fraction acts as an antibody?
α1-globuline
γ-globulins
α2-globuline
8. Phenylketonuria is characterized by increased synthesis of:
a) homogentisic acid
b) dioxyphenylalanine
c) melanin
d) phenylpyruvic acid
9. The cause of positive nitrogen balance is the increased synthesis of:
a) somatotropic hormone
b) insulin
c) glucocorticoid
d) thyroxin
10. The causes of positive nitrogen balance are:
a) lack of androgens
b) lack of insulin
c) pregnancy
d) childhood
Answers:
1abc, 2ab, 3cd, 4ab, 5d, 6c, 7b, 8d, 9ab, 10ab