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Function of Igg â antibodies â solubil Igg â antigen receptor (BCR) â (IgM a IgD on the surface of B cells) ⢠differences in H chain structure (Fc ftagment) determine secondary biological function of antibodies: biological half life, distribution in the body, passing through the placenta, complement activation, binding to cells through Fc-receptor â opsonization, IgE binding on mastocytes etc.