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Transcript
Genetics and Critical Illness 15/3/11 - there is increasing awareness of genetic make up influencing one’s ability to respond in critical illness. SEPSIS - it is now believed that genetic predisposition influences the risk of serious infection and outcome. - thought to be related to single nucleotide polymorphisms (SNP) - influence severity of injury by controlling induction of TNF, NF kappa B and toll receptors - TT LNPEP rs XXX -> inherited mutation that is able to predict the SIRS response to bypass - important genetic polymorphisms: IL-6, TNF alpha, CD14 receptor, protein C halotypes - it is now known that different people have differing MIC’s to various bacteria. ACUTE LUNG INJURY - genetic susceptibility to the development of ALI and ARDS - important gene candidates and potential gene-environment interactions identified. - Mannose binding lectin genes and surfactant protein B gene polymorphism HEAD INJURY - presence of a certain Apo Lipoprotein genes have an adverse outcome in head injury. PHARMACOGENOMICS - response to adverse effects of a drug are thought to have a genetic basis VASCULAR DISEASE - IHD and CVA have some genetic basis Jeremy Fernando (2011)
