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Transcript
Genetics and Critical Illness
15/3/11
- there is increasing awareness of genetic make up influencing one’s ability to respond in
critical illness.
SEPSIS
- it is now believed that genetic predisposition influences the risk of serious infection and
outcome.
- thought to be related to single nucleotide polymorphisms (SNP)
- influence severity of injury by controlling induction of TNF, NF kappa B and toll receptors
- TT LNPEP rs XXX -> inherited mutation that is able to predict the SIRS response to bypass
- important genetic polymorphisms: IL-6, TNF alpha, CD14 receptor, protein C halotypes
- it is now known that different people have differing MIC’s to various bacteria.
ACUTE LUNG INJURY
- genetic susceptibility to the development of ALI and ARDS
- important gene candidates and potential gene-environment interactions identified.
- Mannose binding lectin genes and surfactant protein B gene polymorphism
HEAD INJURY
- presence of a certain Apo Lipoprotein genes have an adverse outcome in head injury.
PHARMACOGENOMICS
- response to adverse effects of a drug are thought to have a genetic basis
VASCULAR DISEASE
- IHD and CVA have some genetic basis
Jeremy Fernando (2011)