* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
Genetically modified food wikipedia, lookup
Frameshift mutation wikipedia, lookup
Gene therapy wikipedia, lookup
Gene expression profiling wikipedia, lookup
Point mutation wikipedia, lookup
Site-specific recombinase technology wikipedia, lookup
Epigenetics of neurodegenerative diseases wikipedia, lookup
Genome evolution wikipedia, lookup
Nutriepigenomics wikipedia, lookup
Gene expression programming wikipedia, lookup
Genetic drift wikipedia, lookup
Genetic code wikipedia, lookup
Artificial gene synthesis wikipedia, lookup
Quantitative trait locus wikipedia, lookup
Biology and consumer behaviour wikipedia, lookup
Polymorphism (biology) wikipedia, lookup
Medical genetics wikipedia, lookup
Heritability of IQ wikipedia, lookup
Behavioural genetics wikipedia, lookup
History of genetic engineering wikipedia, lookup
Human genetic variation wikipedia, lookup
Population genetics wikipedia, lookup
Designer baby wikipedia, lookup
Genetic testing wikipedia, lookup
Genetic engineering wikipedia, lookup
Genetic engineering in science fiction wikipedia, lookup
Pharmacogenomics wikipedia, lookup
Microevolution wikipedia, lookup
Genetics and Critical Illness 15/3/11 - there is increasing awareness of genetic make up influencing one’s ability to respond in critical illness. SEPSIS - it is now believed that genetic predisposition influences the risk of serious infection and outcome. - thought to be related to single nucleotide polymorphisms (SNP) - influence severity of injury by controlling induction of TNF, NF kappa B and toll receptors - TT LNPEP rs XXX -> inherited mutation that is able to predict the SIRS response to bypass - important genetic polymorphisms: IL-6, TNF alpha, CD14 receptor, protein C halotypes - it is now known that different people have differing MIC’s to various bacteria. ACUTE LUNG INJURY - genetic susceptibility to the development of ALI and ARDS - important gene candidates and potential gene-environment interactions identified. - Mannose binding lectin genes and surfactant protein B gene polymorphism HEAD INJURY - presence of a certain Apo Lipoprotein genes have an adverse outcome in head injury. PHARMACOGENOMICS - response to adverse effects of a drug are thought to have a genetic basis VASCULAR DISEASE - IHD and CVA have some genetic basis Jeremy Fernando (2011)