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Immunology Biology 377 California State University-San Marcos Syllabus Semester: Fall 2008 Lecture: Tues/Thurs 10:30-11:45 Lecture location: Markstein 306 Instructor: Dr. Jennie C. C. Chang Office hours: Thurs 12:00-2:00 pm Location: SCI2, Rm141 email: [email protected] (email is the best way to contact me) On-line posting of lecture notes: Go to Yahoo.com, click on mail, “id” to log in is [email protected], password is “csusm377” Check this website for lecture notes and notices about the course. Textbook: Required Kuby Immunology by Richard A. Goldsby, Thomas J. Kindt, Barbara A. Osborne (2007) W.H. Freeman 6th Ed. http://bcs.whfreeman.com/immunology6e/ Optional Case Studies in Immunology by Fred Rosen and R. Geha (2007) Garland Science 5th Ed http://www.bios.co.uk/textbooks/0815341451.asp Course Objectives: Nature and components of innate immunity Cells and functions of adaptive immunity Genes involved in immunity Immune dysfunctions (e.g., autoimmunity), immune functions in infection, cancer and transplantation Grading policy: Exam 1 Exam 2 Exam 3 Report 3 Quizzes Class participation/attendance Total 100 pts 100 pts 200 pts 100 pts 90 pts (30 pts per quiz) 30 pts 620 pts Final grade assignments: A = 93-100% A- = 90-92% B+ = 87-89% B = 83-86% B- = 80-82% C+ = 77-79% C = 73-76% C- = 70-72% D = 60-69% F = < 60% 1 Exams will consist of multiple choice, short answer and essay questions. Make-up exams must be arranged prior to the scheduled exam period. The final examination may not be changed unless approved by the Dean of the College of Arts and Sciences. No make-up final examination will be given except for reasons of illness or other verified emergencies. The report will consist of a 6-8 page paper (1200-1600 words, 12 pt font, double spaced) on a topic of your choice from the Case Studies in Immunology book. To clarify, you can pick a subject from the Case Studies book which we will not cover in class. Give me your preferred topic by Oct. 21, report is due Dec. 4. Attendance: Students can earn a bonus on their total points of 30 points for perfect attendance. (Each absence = 10 points less, each late = 5 points less). Although there are times when missing class cannot be helped, these extra credit points are only for perfect attendance. No excuses for bonus points. Stay healthy. Add/drop class: Students should go to the Express Center (located in CRA 4701). The Center is open from 8 am to 6 pm through the last day of add/drop – September 8, 2008. Absence for the 1st or 2nd class results in administrative drop. Excessive absence in the first 4 weeks also results in administrative drop. Classroom Rules: No talking will be allowed during class. A warning will be given for the first offence, and if it continues, the student will be asked to leave the classroom. Cell phones should be off during class. Plagiarism policy: Any evidence of cheating will result in a failing grade for that assignment and possibly a failing grade for the semester for the course. Please see me if you have any questions about what exactly constitutes plagiarism. Schedule of material to be covered in lectures and exams: DATE Topics and Chapters covered Week 1 Aug 26 Aug 28 Introduction, history of immunology Body’s defense system, innate immunity Week 2 Sep 02 Sep 04 complement system, tissue of the immune system Immunoglobulin structure & function Week 3 Sep 9 Sep 11 Immunoglobulin structure & function, continued Quiz #1; B cell development Week 4 Sep 16 Sep 18 B cell development, continued MHC Week 5 Sep 23 Sep 25 MHC, continued Group discussion, review 2 Week 6 Sep 30 Oct 2 Exam 1 T cell antigen receptor Week 7 Oct 7 Oct 9 Antigen processing Antigen processing, continued; T cell repertoire Week 8 Oct 14 Oct 16 T cell repertoire and self-tolerance Quiz #2; Super antigens Week 9 Oct 21 Oct 23 cytokines; Report topic due Killer cells Week 10 Oct 28 Oct 30 Group discussion, review Exam 2 Week 11 Nov 04 Nov 06 Hypersensitivity, blood transfusion Autoimmunity, Immunodeficiency Week 12 Nov 11 Nov 13 Week 13 Nov 18 Nov 20 Week 14 Nov 25 Nov 27 Week 15 Dec 02 Dec 04 Week 16 Tues, Dec. 9 No class: Veteran’s Day Infectious diseases and immunity Quiz #3; Cancer immunity Transplant immunology The immune system in health and disease continued Immunological methods No class, Thanksgiving holiday Vaccine development; Report due Review Final (comprehensive) Examination 3