Download BIOL 207 - Biological Sciences

DEPARTMENT OF BIOLOGICAL SCIENCES
BIOL 207
MOLECULAR GENETICS AND HEREDITY *3 (3-0-3)
The chromosomal and molecular basis for the transmission and function of genes. The construction
of genetic and physical maps of genes and genomes. Strategies for the isolation of specific genes.
Examples of regulatory mechanisms for the expression of the genetic material in both prokaryotes
and eukaryotes.
Prerequisite: Biology 107.
Term: September - December 2002
Section: A2
Place/Time: ETL E1 007/ MWF, 12:00-12:50
Lecturer: Dr. Heather McDermid
Course Coordinator : Dr. John Locke
Lecturer: Dr. Heather McDermid
Office: Room G508A, Bio.Sci.Bldg.
!!!!!!!!!!!!!Ph. 492-5377
Office Hours: open door
(see schedule on WWW)
email: [email protected]
The laboratory coordinator is:
Dr. Ramesh Bhambhani
!!!!!!!!!!!(Rm. CW312, Bio.Sci.Bldg. 492-5490).
The course technician preparing the labs is:
Ms. Stacey Mebs
!!!!!!!!!!!!(Rm G104 Bio. Sci. Bdg. 492-4511).
Required textbook
The first laboratory session contains
significant work and will take place in the second
week of term (Sept. 15-19). If you have not yet
registered for a laboratory section, you must
contact Dr. Bhambhani as soon as possible.
"An Introduction to Genetic Analysis - 7th
Edition" (2000) by Griffiths et al. This is
available at the U. of A. Bookstore. The
"Student Companion" book has answers to the
problems listed at the back of each chapter in
the textbook.
The Laboratory Manual is on sale in the U of A
Bookstore. Purchase your copy as soon as
possible and well before your first lab period.
You must read Exercise 1 before arriving in the
lab. There is a worksheet to do in the first Lab
period.
The older texts, Griffiths 6th Edition and
Fairbanks & Andersen, are no longer
recommended. I will assume you have the
Griffith's text (7th Edition) and will provide page
references for this text.
The Final Lab Exam is scheduled for:
10:00 AM – 1:00 PM Saturday, Nov 29, 2003.
Some background material can also be found in
the Biol207 Laboratory Manual.
Cheating and Plagiarism are serious academic
offences and are not permitted. See the Code of
Student Behavior (Section 26 in the student
Calendar) and the web site,
www.ualberta.ca/~unisecr/ for the latest revision.
Supplementary information/readings may also be
handed-out, or assigned in class.
Weekly Laboratories
There is a three-hour laboratory session each
week.
Attendance at laboratory sessions is required.
Notice about Cheating and Plagiarism
Students caught cheating or plagiarizing will be
dealt with according to the current Code of
Student Behavior.
http://www.ualberta.ca/~unisecr/gfcPM.htm#30
Biol207 Syllabus: Sept-Dec. 2003, Section A2, Dr. McDermid, 12noon, MWF, ETL E1 007
Page 1
Lecture content
NEW:
Material for the lecture portion of this course
comes from four main sources: lectures (and
related web notes), text readings, problems &
questions assigned in the text, and
supplementary readings. (There is also
significant overlap with the lab content so as to
reinforce certain key concepts.)
FOUR-POINT LETTER GRADING SYSTEM
Students who take advantage of all sources
(including the workshops - see below) to their
fullest extent will be more likely to do better on
the midterm and final exams.
The final grades for Biol 207 will be an
“A+, A, A-, B+, B, B-, C+, C, C-, D+, D, or F”
according to the guidelines in the above web
site.
Grade Assignment and Exams
The 1 through 9 system will not be used.
The final grade will be based on the following
distribution:
40% Laboratory Marks (Lab reports, quizzes,
exam)
20% Mid-term Exam (in lecture period #20)
40% Final Exam
Also see http://www.grades.ualberta.ca
The 40% of the course grade attributed to your
performance in the Laboratory segment of the
course will be explained in more detail in your
Laboratory. There are 10 laboratory exercises for
which Lab Reports or Quizzes may be
required. There is a Lab Exam scheduled for
10:00 AM Saturday Nov 29 '03
There will be a Mid-term Exam during the
lecture period #20 (Mon,Oct 20). Students who
obtain an "Excused Absence" from the Mid-term
Examination will have the 20% weight
transferred to their Final Examination
performance.
The Final Exam for Section A2 is currently
scheduled by the University to be on:
Wednesday, December 10 at 2:00-5:00 PM
Absent from an exam? Anyone with a valid
excuse for missing an exam date should see
sections 23.5 in the 2003/2004 UofA Calendar
(starts on p 65).
The Deferred Final Exam for Biol207 Section
A2 will be held on Monday Jan. 5, 2004 at 09:00
AM. Meet in room G508 Bio. Sci. Building. This
is the only date and time for the deferred final
exam for Biol207 Section A2.
September 2003 marks the introduction of the
new “four-point letter grading system”: see the
following U. of A. web site for more details
http://www.ualberta.ca/~unisecr/policy/sec61.htm
l#6
World Wide Web Pages for Biol207
WWW pages have been constructed for the
Netscape and Internet Explorer web browsers
(most other web browsers will also work).
T h e
a d d r e s s
http://www.biology.ualberta.ca/courses/biol207/
It is also accessible through the Department of
Biological Sciences Home Page
(http://www.biology.ualberta.ca/ ).
These Biol207 pages provide more detailed
course information, readings, and lecture notes.
The "notes" are primarily an on-line version of
the overheads presented in class. Students may
download the text to make inclass note-taking
easier. These notes are not a substitute for the
course or for attendance at lectures. They are
not complete lecture notes.
"Current news" is also available, such as
changes in class content or corrections to the
web pages. Your comments and contributions
are also welcome.
The Laboratory Manual is not available on the
net. You must buy the Laboratory Manual (see
above) from the Bookstore.
Biol207 Syllabus: Sept-Dec. 2003, Section A2, Dr. McDermid, 12noon, MWF, ETL E1 007
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Biol 207-A2 LECTURE OUTLINE !!!!!!!!!September - December, 2003
The dates, lecture numbers and titles are listed. Suggested readings and problems assigned will
be available on the McDermid 207 website as the webnotes for each lecture are made available.
Date
Lecture # and Title
Wed Sep 3 !1. Course Intro + !DNA is the genetic material
Fri
Sep 5 !2. Chromosome replication 1
Mon Sep 8 !3. Chromosome replication 2
Wed Sep 10 !4. Genes encode proteins 1
Fri
Sep 12 !5. Genes encode proteins 2
Mon Sep 15 !6. Mutations originate as damage to DNA
Wed Sep 17 !7. DNA repair
Fri
Sep 19 !8. Classification of mutations
Mon Sep 22 !9. Introduction to gene regulation and operons
Wed Sep 24 10. Induction of the lac operon
Fri
Sep 26 11. Eukaryote gene structure and regulation
Mon Sep 29 12. Alleles, Dominance & Segregation (Mendel's 1st law)
Wed Oct 1 13. Chromosomes
Fri
Oct 3 14. Chromosome behavior in Meiosis, and life cycles
Mon Oct 6 15. Genetic implications of Meiosis
Wed Oct 8 16. Independent assortment, dihybrid crosses
Fri
Oct 10 17. Linkage
Mon Oct 13
Thanksgiving Monday - no class
Wed Oct 15 18. Sex chromosomes and sex linkage
Fri
Oct 17 19. Catch-up
Mon Oct 20 20. * * * * Midterm exam * * * *
Wed Oct 22 21. Mapping 3 loci (3 point crosses) 1
Fri
Oct 24 22. Mapping 3 loci (3 point crosses) 2
Mon Oct 27 23. Pedigree analysis
Wed Oct 29 24. Chromosome rearrangements
Fri
Oct 31 25. Changes in chromosome number - Ploidy
Mon Nov 3 26. Gene interactions and epistasis
Wed Nov 5 27. Physical mapping of genes, chromosomes
Fri
Nov 7 28. Genome projects
Mon Nov 10
Remembrance Day Holiday - no class
Wed Nov 12 29. Clones and DNA libraries
Fri
Nov 14 30. Identifying genes by complementation
Mon Nov 17 31. Identifying clones using DNA probes
Wed Nov 19 32. Isolation of genes by Transposon Tagging
Fri
Nov 21 33. Gene manipulation
Mon Nov 24 34. PCR and it’s uses
Wed Nov 26 35. Restriction Fragment Length Polymorphism (RFLP) 1
Fri
Nov 28 36. Restriction Fragment Length Polymorphism (RFLP) 2
Mon Dec 1 37. Mendelian and molecular genetics combined
Wed Dec 3 38. catch-up
Copyright © 2002 Heather McDermid, Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
Biol207 Syllabus: Sept-Dec. 2003, Section A2, Dr. McDermid, 12noon, MWF, ETL E1 007
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Notes about assigned problems for lectures:
Most lectures have assigned problems. The only way to learn the concepts in this course is to
do the problems.
Answers to all these problems can be found in the "Solutions Manual" (soft cover) that came
with the text (hard cover). Look at the answer ONLY after you have tried your best at the
problem. Just reading the answer will not help you learn the concepts.
Don’t understand the problem? - look again and review the text material.
Still don’t understand the problem? See Dr. McDermid or the tutorial assistant.
More problems:
Sample midterm and final exams will be available at Dr. McDermid's Biol207 Web site.
More problems will also be presented in the weekly workshops by the TAs.
Biol 207 Workshops:
The Department of Biological Sciences has received funding from the VP Academic to add
new "Workshops" to the first-year and second-year core courses. These smaller-group classes
come in response to student’s concerns over the problems inherent in large introductory
classes.
The objectives of the Biol207 Workshops are:
1. To increase the quantity and quality of interaction between undergraduate students and
instructional staff of the University so that students may learn better.
2. To promote "active learning" and enhanced understanding of the Biology 207 curriculum
through student participation in topic reviews and problem solving.
3. To provide students with timely feedback on their learning of the Biology 207 curriculum so
that they may correct any deficiencies in Biol207 content or understanding prior to
examination.
4. To improve student performance on Biol207 exams.
Workshop Registration:
Every student should be registered in a Biology 207 Workshops; it is mandatory. There are 10
weeks of sessions and the first begins week of September 15th. (See schedule below.)
Each Workshop is a 50-minute session. All Workshops will take place in G116 Biological
Sciences Building (basement of the Genetics wing - south west side) at the following days
and times:
Section A1 (Dr. Locke)
Section A2
(Dr. McDermid)
E01
Monday
9:00-9:50AM
E06
Tuesday
9:00-9:50AM
E02
Monday
10:00-10:50AM
E07
Tuesday
10:00-10:50AM
E03
Thursday
2:00-2:50PM
E08
Tuesday
11:00-11:50AM
E04
Thursday
3:00-3:50PM
E09
Wednesday 4:00-4:50PM
E05
Thursday
4:00-4:50PM
E10
Wednesday 5:00-5:50PM
Biol207 Syllabus: Sept-Dec. 2003, Section A2, Dr. McDermid, 12noon, MWF, ETL E1 007
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Biol207 Workshop Schedule - Fall – Sept-Dec. 2003
Date
Workshop#
Lecture#
Sept 3 - 5
No workshops
1-2
Sept 8 - 12
No workshops
3-5
Sept 15 - 19
Workshop#1 -
6-8
Sept 22 - 26
Workshop#2
9-11
Sept 29-Oct 3
Workshop#3
12-14
Oct 6 - 10
Workshop#4
15-17
Oct 13 - 17
Workshop#5 - Midterm exam review
18-19
Oct 20 - 24
Workshop#6
20-22
Oct 27 - 31
Workshop#7
23-25
Nov 3 - 7
Workshop#8
26-28
Nov 10 - 14
No workshops
29-30
Nov 17 - 21
Workshop#9
31-33
Nov 24 - 28
Workshop#10 - Final Exam Review
34-36
Dec 1 - 3
No workshops
37-38
Note:
The best way to study for Biol207 exams is to "Do the problems!"
Of the students last year (Fall term Sept-Dec'02) who received a grade of either 8 or 9, onethird went to 8-10 of the workshops and two-thirds went to five or more workshops.
Use these workshops to improve your understanding and your grade.
Biol207 Syllabus: Sept-Dec. 2003, Section A2, Dr. McDermid, 12noon, MWF, ETL E1 007
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