Download 03-390 Molecular and Cellular Immunology - Syllabus

03-390 Immunology
August 22, 2016
03-390 Molecular and Cellular Immunology - Syllabus
Instructors:
Dr. Gordon Rule: [email protected]
Office hours are best by appointment.
Text: Immunology – Immunology - A short course.
Course Website: http://www.andrew.cmu.edu/user/rule/03_390/index.html. (Lec notes, Jmol links)
OLI: Weekly Post-lecture Quizzes
Blackboard: Links, Gradebook + Pre-lecture Quizzes
Course Description: This course offers the student a comprehensive view of modern immunology at the
molecular and cellular level. The first half of the course presents the fundamentals of immunology, beginning
with innate immunity and followed by a discussion of the structure and function of important molecules in the
immune system, such as antibodies, major histocompatibility antigens, complement and the T-cell receptor.
This portion of the course concludes with a discussion of the development and function of the cellular
immune response. The second half of the course is focuses on applied immunology and discusses use of
antibodies in medicine and biotechnology, hypersensitivity, autoimmunity, immunodeficiency, tumor
immunology, infectious disease, and transplantation immunology. Presentation and research proposal at the
end of the course provide an opportunity for the student to explore additional topics in contemporary
immunology.
Prerequisites: Biochemistry I (03-231 or 03-232) and Cell Biology (03-240), or permission of instructor.
Learning Objectives: This course is intended to teach the student the following: major immunological
pathways, cells, and molecules of the immune system; functional interdependence of immune cell types; ways
in which molecules that function in the immune system interact; how diversity in the immune system is
generated; various methods of analysis that exploit immune molecules and processes; functions of immune
cells and molecules in clinical settings such as infection, inflammation, autoimmunity, hypersensitivity,
transplantation, and cancer. Students will also develop skills in the reading of the primary literature through
prompt based essays and in oral presentations of self-selected topics in contemporary immunology the end of
semester presentation.
Course Activities and Tentative Grading: A >90, B 80-90, C 65-79, D 50-65, R <50.
Exams [60%]: A total of three exams, two during the semester and one during finals week. The last exam will
be more comprehensive than the earlier exams due to the broad nature of the material in the latter period
of the course. One half of the lowest exam grade will be dropped in the calculation of the final grade (2 x
24 + 12). You are only responsible for material delivered in lecture, clearly assigned text readings, and incourse assignments.
Writing Assignments [15%]: Approximately 5 literature-based writing assignments will be assigned during the
semester. Although you are welcome to discuss the journal articles with your classmates and the instructor,
the completed work must be solely your own.
In-class presentations [10%]: In-class student presentations will be given in the last class periods. Groups of 13, students will present the most important aspects of a topic in contemporary immunology. The topic
chosen by the group must be submitted to the instructor for approval no later than 2 weeks before the
presentations. The presentations should be approximately 10 minutes including 2 minutes for questions.
The presentation will account for 5% of the final grade. In addition, each group will prepare a 1-page
summary of their presentation to be distributed to the class prior to their presentation. This summary will
be worth 5% of the final grade.
OLI quizzes [5%]: There will be 13 weekly quizzes delivered by OLI. These quizzes are closed book – do not
consult the text or notes while you are taking the quiz. These quizzes will test the key concepts for that
week’s lecture; consequently, they will give students an opportunity to assess how well they have
understood the material. In addition, the quizzes will give the instructors feedback on how well a concept
was taught and if additional class time is required to discuss that material.
Generally, the quizzes will be available from Wednesday at 12:00 noon until the following Monday at
11:59 PM. Students will have 20 minutes to complete the 4-12 questions. Two attempts will be allowed,
and the highest grade will be used. The quizzes are generated from pools of questions, thus questions on
each attempt may be different. The scores for the best 10 quizzes will be used to calculate your grade.
Problem Sets and Pop-quizzes [10%]: Several problem sets and a number of “pop-quizzes” will be assigned.
How to succeed in this course: The immune system is very complex with many interrelationships.
 Attend class and take notes in class. Review your notes before attempting the weekly quiz.
 Read the appropriate section of the text to gain a deeper understanding of the material.
 Ask questions in class if topics are unclear.
 Meet with the instructors and teaching assistant if you are having trouble with any of the concepts.
03-390 Immunology
August 22, 2016
Academic Integrity: Please review the section on academic integrity on the CMU website. Any work that is
turned in for credit must be your own.
Tentative Schedule:
OLI Q
Date
Aug 22 (M)
Q1
Aug 24 (W)
Aug 29(M)
Q2
Aug 31(W)
Sep 5(M)
Q3
Sep 7(W)
Sep 12(M)
Sep 14 (W)
Sep 19(M)
Q4+5
Sep 21(W)
Sep 26(M)
Sep 28(W)
Oct 3(M)
Q6
Oct 5(W)
Oct 10(M)
Q7
Oct 12(W)
Oct 17(M)
Q8
Oct 19(W)
Oct 24(M)
Oct 26(W)
Q9
Oct 31(M)
Nov 2(W)
Nov 7(M)
Q10
Nov 9(W)
Nov 14(M)
Q11
Nov 16(W)
Q12
Nov 21(M)
Q13
Nov 23(W)
Nov 28(M)
Nov 30(W)
Lec
1
2
3
4
5
6
Topic
Overview of Immunology - Innate Immunity
Complement
Cytokines & Inflammation
Innate response to virus, NK cells, TLR3, interferons
Overview of acquired immunity - B and T cells/Anatomy
Chemical and Biological properties of Antibodies
Eid - no class
Eid - no class
7
8
9
Genetic changes during antibody production
10
11
12
13
14
15
16
17
18
MHC Structure and antigen presentation
19
20
21
22
23
24
Immunodeficiences - primary
Regulation and Expression of BCR
MHC Genetics
Exam I (lectures 1-8)
Receptor+Antigen interactions
Immunological methods I
Immunological methods II
Development & Activation of T-cells
Tolerance and Control of immune response
Infectious disease I
Infectious disease II
Vaccines
Exam II (Lectures 9-17)
Immunodeficiences - acquired
Allergy and hypersensitivities I
Hypersensitivities II-IV
Transplantation
Cancer Immunology
Student presentations
Student presentations
Exam III