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Transcript
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Chloramphenicol
Chlorpropamide
Citalopram
• Leflunomide
• Levothyroxine
• Linezolid
• Saquinavir*
• Sertraline
• Sirolimus
Clofibrate
Clozapine
Corticosteroids
Cyclosporine
Dapsone
Darunavir*
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Lopinavir*
Lorcainide
Losartan
Maraviroc
Medroxyprogesterone
Mefloquine
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Sorafenib
Sunitinib
Tacrolimus
Tadalafil
Tamoxifen
Telithromycin
Dasatinib
Deferasirox
Delavirdine
Diazepam
Digoxin
Diltiazem
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Methadone
Metoprolol
Mexiletine
Midazolam
Mifepristone
Monteleukast
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Temsirolimus
Terbinafine
Theophylline
Tinidazole
Tipranivir*
Tocainide
Disopyramide
Doxycycline
Dronaderone
Efavirenz
Erlotinib
Estazolam
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Morphine
Moxifloxacin
Mycophenolate
Nelfinavir
Nevirapine
Nifedipine
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Tolbutamide
Tolvaptan
Tramadol
Triazolam
Trimetrexate
Valproic acid
Eszopiclone
Estrogens
Etravirine
Everolimus
Fentanyl
Fesoterodine
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Nilotinib
Nisoldipine
Oral Contraceptives
Oxycodone
Pazopanib
Pioglitazone
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Verapamil
Voriconazole*
Warfarin
Zaleplon
Zidovudine
Zolpidem
Miscellaneous drug interactions with rifampin are as follows:
• Bosentan – trough level is initially increased, then at steady state blood levels are decreased
• Carbamazepine – rifampin may inhibit its metabolism, resulting in increased blood levels
• Eltrombopag – is an OATP1B1 inhibitor that is in turn inhibited by rifampin; concurrent administration of an
OATP1B1 substrate results (for example, rosuvastatin) results in increased blood levels of the substrate
• Enalapril – decreased efficacy due to increased clearance of active metabolite
• Entacapone – increased blood levels due to interference with biliary secretion
• Ethionamide – increased risk of hepatotoxicity
• Levomethadyl – increased risk of QT prolongation, torsades de pointes
• Probenecid – increases rifampin blood levels
• Valsartan – increased blood levels due to OATP1B1 inhibition by rifampin