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Lab.4 3rd-year class Practical Pharmacology 2010-2011 Problem solving(pharmacokinetics) Problem No.1 The maximum oral dose for propranolol in treatment of hypertension may be up to 320 mg per day(in 3 divided doses),while the maximum intravenous dose of the same drug is only 10 mg for the treatment of cardiac arrhythmias.(Discuss) Problem No.2 A patient on warfarin for the treatment of deep venous thrombosis (DVT) developed bleeding per rectum after receiving therapeutic doses of indomethacin (NSAIDs) for severe pain in the inflamed lower limb.(Discuss) Problem No.3 A 20 years old epileptic female patient has been well controlled on carbamazepine tablet;200 mg twice daily. She developed dizziness,diplopia and ataxia following prescription of erythromycin for tonslitis.(Discuss) Problem No.4 A patient with severe renal impairment, his doctor prescribed for him gentamycin 40 mg three times daily for treatment of urinary tract infection. The nurse, by mistake, gave him an ampoule of 80 mg three times daily. He developed deafness. What is the possible explanation? Problem No.5 A 60 years old patient was diagnosed to have angina pectoris. He was put on propranolol 40 mg three time daily for the last six months . He traveled to the north of Iraq ,but forgot to take his propranolol tablets with him. After one day of stopping his treatment , he experienced exacerbation of his anginal attacks which were worse than his attack before treatment.(Discuss)