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RIFAXIMIN (XifaxanÂ®) Usual dose Adult: 200-400 mg Q8H PO (UWHC cost/day $24.06-48.12) Indications 1. Travelersâ diarrhea. 2. Reduction of the risk of recurrence of overt hepatic encephalopathy (NOT approved for treatment) Comments In the limited studies that have been done with Rifaximin in the reduction of the risk of recurrence of overt hepatic encephalopathy, the most effective dose was found to be 600 mg Q12H. However, it was not possible to manufacture a tablet this large; the largest tablet that could be manufactured was a 550 mg tablet. This was the tablet that was used in the pivotal trial for FDA approval for the hepatic encephalopathy indication, but this dose is not the optimal dose for this indication. RITONAVIR For up-to-date information on the use of antiretrovirals, consult an HIV expert or www.aidsinfo.nih.gov/ SAQUINAVIR For up-to-date information on the use of antiretrovirals, consult an HIV expert or www.aidsinfo.nih.gov/ SPECTINOMYCIN No longer available in the U.S. STAVUDINE For up-to-date information on the use of antiretrovirals, consult an HIV expert or www.aidsinfo.nih.gov/ STREPTOMYCIN Usual Dose Adult: 15 mg/kg/day (max 1 g) or 20-40 mg/kg (max 1.5 g) two or three times per week IM (UWHC cost/day $10.1515.22). Indications 1. Mycobacterium tuberculosis â initial treatment in combination with isoniazid, rifampin and pyrazinamide in situations where ethambutol is contraindicated or ineffective (see Appendix E). 2. Streptococcal or enterococcal endocarditis caused by high-level gentamicin-resistant but streptomycin-sensitive strains. 3. Plague, tularemia, or brucellosis. Comments Monitor serum drug levels (test must be sent out). Use extreme caution and reduce dose when prescribing for patients with renal insufficiency. SULFADIAZINE Usual Dose Adult: Load 2-4 g PO; Maintenance 500 mg-2 g Q6H PO (UWHC cost/day $7.40-29.62). Pediatric:** 120 - 150 mg/kg/day PO in divided doses Q4-6H. Indications 1. Toxoplasmosis - treatment of choice. Use in combination with pyrimethamine (1-1.5 g Q6H PO for 3-6 weeks, then 1 g BID PO for maintenance dosing). Comments Sulfadiazine is not recommended for use in infants less than 2 months of age with the exception of congenital toxoplasmosis treatment (in combination with pyrimethamine) where the benefit might exceed the risk. Do not confuse with sulfasalazine.