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Appendix M: Guidelines for the Prophylaxis and Management of Intraabdominal, Biliary, and Appendiceal Infections University of Wisconsin Hospital and Clinics Intraabdominal Infections â Prophylaxis and Management Guidelines developed by: Barry Fox, MD Reviewed and approved by: Surgical QA Committee, Antimicrobial Use Subcommittee Approved by P&T: Scheduled for Review A. Background B. Surgical Prophylaxis C. Source Control D. Categorization E. Treatment by Category F. Cholangitis and Cholecystitis G. Duration of therapy H. Necrotizing Pancreatitis ________________________________________________________________ A. Background This guideline is intended to provide evidence-based guidance for surgical prophylaxis and the treatment of intraabdominal infections. It is based on the 2009 revision of the Infectious Diseases Society of America/Surgical Infection Society update of their joint guideline.1 The guideline is stratified according to the severity of infection and risk of treatment failure, and antimicrobial recommendations are targeted accordingly. B. Surgical Prophylaxis The UWHC Antimicrobial Use Guidelines (AMUG) include a section on surgical antimicrobial prophylaxis.2 Use of the appropriate antimicrobial regimen for the appropriate duration is of paramount importance in gastrointestinal surgeries. Table 1 shows the prophylaxis regimens recommended in the AMUG.