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1.2.3.5.1. 1.2.4. Prescriber should be contacted prior to initiating graded challenge 1.2.3.5.2. Anaphylaxis treatment medications should be available The pharmacist should contact the prescriber if: 1.2.4.1. The type of rash cannot be ascertained, in which case it should be assumed to be urticarial (IgG mediated).11 1.2.4.2. The patientâs history is positive for an IgE-mediated (type 1) reaction. 1.2.4.3. The reaction is a severe, non-IgE-mediated reaction.