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1.3.8 Sub-therapeutic response to drug therapy 1.4 The clinical pharmacist is responsible for determining the sample time of the SDC. 1.5 The order for a SDC may be overridden, at any time, by the prescriber writing âSerum Drug Concentration as Writtenâ or other equivalent orders. 1.6 The clinical pharmacist is responsible for interpreting and evaluating the results of the SDC and making appropriate recommendations. When evaluating the results of the SDC, the pharmacist should take into consideration factors such as the indication for use of the drug, the target serum concentration, the acute or chronic nature of the drug therapy, and the patientâs clinical status. See the UWHC Adult Pharmacokinetic Guideline for assistance in interpreting concentrations. 2.0 Procedure for Managing the Ordering of Serum Drug Concentrations 2.1 The pharmacist is responsible for monitoring drug therapy and SDC on a routine basis. 2.2 If a patient is receiving a drug routinely monitored by SDC, the pharmacist will determine the need for a SDC. 2.3 If a SDC is indicated, the pharmacist will: 2.3.1 Determine the appropriate time of SDC by referring to the UWHC Adult Pharmacokinetics Guideline, UWHC Lab Handbook, MICROMEDEXÂ®, or current literature. 2.3.2 Write an order for the SDC along with the indication for the concentration and the appropriate sample time and date. 2.3.3 The order shall state, âSerum Drug Concentration per protocolâ and be signed by the pharmacist. 2.4 If the physician orders a SDC and indicates âSDC as written,â then this information will be recorded on the pharmacy monitoring notes. The pharmacist will indicate the appropriate sampling time on the original order if not already indicated. 2.5 If the physician orders âSDC per pharmacistâ or âlevels per pharmacistâ, the clinical pharmacist shall determine the indication for the concentration(s), date and time. The pharmacist shall document this in the patientâs orders and sign, date, and time the order. If the pharmacist determines that no SDC is indicated, they shall discuss the indication with the ordering physician. If there is agreement that no SDC is required, then the pharmacist will write an order to discontinue the SDC. If there is not agreement and the ordering physician is a resident who requests a SDC even though protocol indicates otherwise, then an order by the attending physician is required to overrule the pharmacist and the protocol. 2.6 The results and assessment of the SDC will be recorded in the pharmacy monitoring note and the patientâs chart. 2.7 If a change in dose is indicated as a result of the SDC, the pharmacist will verbally contact the physician to initiate the change and record this information in the pharmacy monitoring notes and the patientâs chart on the same shift that the results become available.