Download Name Student ID Oct 29,2015 Choose the BEST alternative. What

Name _________________________________ Student ID _________________________________ Oct 29,2015
Choose the BEST alternative.
1. What event is a central element of the mode of action of Cytotoxic T cell (CTL)
interaction with a virus-infected target cell?
a. They secrete perforins that create pores in the membrane of target cells
b. They secrete cytokines that stimulate growth and activation of B cells.
c. They inhibit the immune response.
d. They initiate delayed responses to antigens.
e. They contribute to the initiation of classical complement pathway.
2. MHC Class II molecules are made up of two chains called _______, whose function is to
bind peptides and present them to _______ T cells:
a. alpha (α) and beta (β); CD4
b. alpha (α) and beta2-microglobulin; CD4
c. alpha (α) and beta (β); CD8
d. alpha (α) and beta2-microglobulin ; CD8
e. alpha (α) and beta2-microglobulin; gamma-delta
3. Positive and negative selection occurs in the thymus in order to:
a. Delete autoreactive T cells by apoptosis
b. Activate T cells with foreign antigen
c. Determine if cells can recognize self MHC at a low level as part of dual
recognition
d. Determine if cells can recognize foreign MHC
e. Both a and c
4. What is one of the major roles of the complement cascade in the body's defense
against infection?
a. It interferes with intracellular viral replication
b. It is responsible for antibody production by B cells
c. It aids in MHC mediated antigen presentation
d. It produces the Membrane Attack Complex (MAC) and perforates the
plasma membrane
e. It reduces inflammatory processes that are initiated by antibody binding to
antigen
5. When the innate immune system encounters a foreign antigen, which of the kinds of
cell-surface molecule listed below will play an important role in the recognition of
that foreign antigen?
a. Antibody
b. T cell receptor
c. MHC Class I
d. MHC Class II
e. Toll-like receptor (TLRs)
6. Cytokine function can be
a. Pleomorphic (with different effects under different circumstances)
b. Antagonistic (with opposing effects for other cytokines)
c. Synergistic (expanding other cytokine effects beyond a simple additive effect)
d. Redundant (capable of replacing the effects of a different cytokine)
e. All of the above
Name _________________________________ Student ID _________________________________ Oct 29,2015
7. Rearrangement of the TcR alpha and beta genes occurs
a. Using the same enzymatic processes that are employed by B cell H and L
chain genes
b. Using the same sequences of DNA that produce antibody, just rearranged
differently
c. Using the same J chain elements
d. All of the above are true
e. None of the above are true
8. Polyclonal stimulation of T cells can be accomplished with
a. Anti-CD3 antibody
b. Endotoxin
c. Anti-idiotypic antibody
d. Anti CD4 antibody
e. Anti-CD8 antibody
9. Viral immunity in some cases (e.g. influenza) must be re-induced by vaccination each
year because antigen shifts occur. These shifts are the result of
a. Point mutations that alter the antigenic epitopes of the virus
b. Failure of the immune response to persist beyond a single year
c. The failure of some people to get immunized
d. New combinations of antigenic epitopes that result from co-infection of a
single cell by two different viruses and the production of a new virus
that combines proteins from two different viral progenitors
e. Failure of some production batches to produce immunogenic vaccine
10. How does the immune system segregate endogenous peptide presentation from the
presentation of exogenous peptide presentation on the MHC class I and class II
molecules respectively?
a. By separating the processes to entirely different cell types
b. By limiting endogenous presentation to the thymus as a way to allow both
positive and negative selection to occur
c. By segregating the point in the process of antigen loading that MHC class
I encounters antigen from the time that the invariant chain is
dissociated from MHC class II.
d. By trafficking each of the MHC molecules to the plasma membrane by a
different and unique process
e. None of the above explain the segregation of MHC class I and II processing and
presentation.