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BI432 Immunology Exam #2 Winter, 1997 1 Name: 1. ANSWER EITHER “1A” OR “1B” POINTS WILL BE DEDUCTED FOR ANSWERING BOTH!! 1A. Complete the following table by placing a “D” for DNA in boxes indicating a rearrangement that occurs at the level of the gene, an “R” for RNA in boxes indicating a rearrangement that occurs at the level of transcript processing and an “N” for NO in boxes indicating rearrangements that do not occur. (20) H chain TCR TCR LV VJ VD DJ JC 1B. Complete the following table by placing a “D” for DNA in boxes indicating a source of diversity that occurs at the level of the gene, an “P” for PROTEIN in boxes indicating a source of diversity that occurs at the level of the protein and an “N” for NO in boxes indicating a sources of diversity that do not exist. (20) H chain TCR TCR combinatorial joining alternative D gene segment joining junctional flexibility somatic mutation combinatorial associaton of chains 2. What gene rearrangement, transcription or transcript processing event(s) determine whether the membrane or secreted forms of the heavy chain is expressed? (10) 3. ANSWER EITHER “3A” OR “3B” POINTS WILL BE DEDUCTED FOR ANSWERING BOTH!! 3. A. Diagram a class I MHC antigen and state the cells on which the class I MHC antigen is expressed (10 pts) 3.B. Diagram a class II MHC antigen and state the cells on which the class II MHC antigen is expressed (10 pts) I am answering question 3_____. 4. Define each of the following and BRIEFLY state the role, if any, of the structure or process in generating diversity in expression of MHC genes. (15 points) allelic polymorphism: cellular expression of MHC peptides 5. Define ONLY TWO of the following terms and state IN ONE SENTENCE the role of the term in antigen processing. (5 points each) invariant chain ubiquitin transporter of antigenic peptides BI432 Immunology Exam #2 Winter, 1997 Name: 6. Several membrane molecules, in addition to the T-cell receptor, are involved in antigen recognition and T cell activation. Describe the properties and distinct functions of ANY TWO AND ONLY TWO of the following T-cell membrane molecules (10 points) CD3 CD 4 and CD8 CD2 7.A. What function is common to NF-B, NF-AT and CD28RC during the activation of TH cells?(7 points) 7.B. How do NF-B, NF-AT and CD28RC differ in their involvement in the activation of TH cells? (8 points) 8. Briefly describe the similarities and differences among cytokines, growth factors and hormones. (10 points) 3 9. ANSWER EITHER “9A” OR “9B” POINTS WILL BE DEDUCTED FOR ANSWERING BOTH!! 9. A. Complete the following table. (15 pts) Property Primary Antibody Response Secondary Antibody Response Responding B cell Lag period following antigen administration Time & magnitude of peak antibody response Isotype produced Antigens Antibody affinity 9. B.. Complete the following table. (15 pts) Location in lymph node Paracortex Primary Follicle Secondary Follicle Germinal Center: Dark Zone Secondary Follicle Germinal Center: Basal Light Zone Secondary Follicle Germinal Center: Apical Light Zone Secondary Follicle Germinal Center: Follicular Mantle Event(s) in B-cell immune response