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Internal Medicine
5. Cardiomyopathy
Learning objectives: at the end of this lesson the student will be able to:
1. Define Cardiomyopathy.
2. List the etiologies of Cardiomyopathies.
3. Describe the different types of Cardiomyopathies.
4. Understand the Epidemiology of Cardiomyopathies.
5. Describe the pathogenesis of Cardiomyopathies.
6. Identify the clinical manifestation of Cardiomyopathies.
7. Understand the diagnostic approach of Cardiomyopathies.
8. Understand the management of patients Cardiomyopathies.
Cardiomyopathies are a group of diseases that affect the myocardium and are not the result of
hypertension, valvular, coronary or pericardial abnormalities. Cardiomyopathies are frequently
associated with myocardial dysfunction and subsequently heart failure. With few exceptions,
histologic findings are nonspecific, with myocyte hypertrophy, cellular necrosis, and fibrosis.
Etiologic classification of Cardiomyopathies:
Primary Myocardial Involvement
Eosinophilic endomyocardial diseases
Endomyocardial Fibrosis
Secondary myocardial involvement:
Infective Myocarditis: Viral , bacterial , fungal , protozoal , Metazoal , Spirochetal
Metabolic : Thyrotoxicosis
Familial storage diseases: Glycogen storage diseases , Hemochromatosis ,
Deficiencies : Electrolyte , Nutritional ( Vitamin B1 deficiency )
Connective tissue diseases : SLE , polyarteritis nodosa , Rheumatoid arthritis ,
Systemic sclerosis
Infiltration and granulomas ; Amyloidosis , sarcoidosis , malignancies
Neuromuscular : muscular dystrophies ,myotonic dystrophies