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Transcript
Internal Medicine
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Any disseminated endemic mycosis (e.g. histoplasmosis, coccidiodomycosis)
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Esohagial Candidiasis ( involving esophagus, trachea, bronchi or lungs )
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Recurrent Bacterial pneumonia
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Recurrent septicemia
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Disseminated atypical mycobacterium
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Extrapulmonary tuberculosis
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Lymphoma ( cerebral or B-cell Non Hodgkin’s lymphoma )
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Invasive cervical carcinoma
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Kaposi’s sarcoma
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HIV encephalopathy
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Symptomatic HIV associated neuropathy.
Antiretroviral Drugs (ARTs)
ARTs are the corner stone of medical management of HIV infection.
Classes of Antiretroviral Drugs
1) Nucleoside reverse transcriptase inhibitors ( NRTIs)
Lamivudine (3TC)
Stavudine ( d4t )
Zidovudine (AZT
Abacavir ( ABC)
Didanosine (DDI )
Zalcitabin ( DDC )
Emtricitabine (FTC)
Tenofovir (TDF ),
Mechanism of Action: Structurally these drugs resemble naturally occurring nucleosides and
break the formation of viral DNA by breaking the chain ( chain breakers )
Zidovudine (AZT)
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Dosage:300mg PO BID
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Side effects: Anemia, Myalgias, bone Marrow Suppression
Lamivudine (3TC):
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Dosing: 150mg BID or 300mg QD
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Side effects :Headache , occasional nausea
Stavudine (d4T)
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Dosing: 40 mg BID for weight > 60 kg , 30 mg BID for weight < 60 kg
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Side effects :Peripheral Neuropathy (5-15%) ,Lactic acidosis, Pancreatitis
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