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Internal Medicine
Abacavir (ABC)
Dosing: 1 x 300mg tablet BID
Toxicity: Allergic reaction (Hypersensitivity reaction) which occurs within first 6 weeks of
initiation of therapy. Never re challenge the patient again with ABC
Tenofevir (TDF): is actually, a nucleoTIDE
Dosing: 1 x 300mg tablet QD
Toxicity: Headache, Nausea, Diarrhea, Lactic acidosis
Didanosine (ddI)
1 x 400mg enteric coated capsule QD (if <60kg: 250mg QD)
2 x 100mg buffered tab BID or 4 x 100mg QD (if <60kg: 125 mg BID or 250mg QD)
NOTE: If use buffered tablets, 2 or more tablets must be used at each dose to provide adequate
250mg of reconstituted buffered powder BID (if <60kg: 167mg BID)
Didanosine (ddI) (2)
Food Interactions: take on empty stomach
Toxicity: Peripheral Neuropathy, Nausea, abdominal pain, Pancreatitis, Lactic acidosis
2) Non-nucleoside reverse transcriptase inhibitors ( NNRTIs)
Nevirapine (NVP, Nevipan®)
Efavirenz (EFV, Stocrin®)
Delavirdine (DLV, Rescriptor®), rarely used
Mechanism of Action: inhibit the active site of Reverse transcriptase enzyme
Nevirapine (NVP, Nevipan®)
Dosing: 200 mg QD x 2 weeks, then 200 mg BID
Skin rash (17%) may be
Milder form (dry rash ) : erythematous, maculopapular rash
Treatment: continue medication with close observation antihistamins may be
Severe form (wet rash): with mucous membrane involvement, Steven’s Johnson
Syndrome and Toxic epidermal necrolysis (TEN)
Rx:- Discontinue medication, never re-challenge