Download Internal Medicine - The Carter Center

Survey
yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project

Document related concepts

Infection wikipedia, lookup

Disease wikipedia, lookup

Management of multiple sclerosis wikipedia, lookup

Multiple sclerosis research wikipedia, lookup

List of medical mnemonics wikipedia, lookup

Dental emergency wikipedia, lookup

Sjögren syndrome wikipedia, lookup

Adherence (medicine) wikipedia, lookup

Syndemic wikipedia, lookup

Focal infection theory wikipedia, lookup

Transcript
Internal Medicine
Abacavir (ABC)
•
Dosing: 1 x 300mg tablet BID
•
Toxicity: Allergic reaction (Hypersensitivity reaction) which occurs within first 6 weeks of
initiation of therapy. Never re challenge the patient again with ABC
Tenofevir (TDF): is actually, a nucleoTIDE
Dosing: 1 x 300mg tablet QD
Toxicity: Headache, Nausea, Diarrhea, Lactic acidosis
Didanosine (ddI)
Dosing
1 x 400mg enteric coated capsule QD (if <60kg: 250mg QD)
Or
2 x 100mg buffered tab BID or 4 x 100mg QD (if <60kg: 125 mg BID or 250mg QD)
NOTE: If use buffered tablets, 2 or more tablets must be used at each dose to provide adequate
buffer.
Or
250mg of reconstituted buffered powder BID (if <60kg: 167mg BID)
Didanosine (ddI) (2)
Food Interactions: take on empty stomach
Toxicity: Peripheral Neuropathy, Nausea, abdominal pain, Pancreatitis, Lactic acidosis
2) Non-nucleoside reverse transcriptase inhibitors ( NNRTIs)
•
Nevirapine (NVP, Nevipan®)
•
Efavirenz (EFV, Stocrin®)
•
Delavirdine (DLV, Rescriptor®), rarely used
Mechanism of Action: inhibit the active site of Reverse transcriptase enzyme
Nevirapine (NVP, Nevipan®)
Dosing: 200 mg QD x 2 weeks, then 200 mg BID
Toxicity:
•
Skin rash (17%) may be
o
Milder form (dry rash ) : erythematous, maculopapular rash
ƒ
Treatment: continue medication with close observation antihistamins may be
administered
o
Severe form (wet rash): with mucous membrane involvement, Steven’s Johnson
Syndrome and Toxic epidermal necrolysis (TEN)
ƒ
Rx:- Discontinue medication, never re-challenge
125