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Transcript
Internal Medicine
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A major feature of this entity is the development of dementia, which is defined as a
decline in cognitive ability from a previous level.
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TRIAD : cognitive, motor and behavioral dysfunction
Table I-5-2. Stages of ADIS dementia complex
Cognition
Early
Inability
Behavior
to
Motor
Altered
Concentrate
personality
Mental Slowing
Social
Poor
Middle
Forgetfulness
withdrawal
coordination
Late
Global
Apathy
Paraparesis
dementia
Diagnosis:
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Neuropsychological tests
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Mini-mental test
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It is often a diagnosis of Exclusion
Treatment:
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HAART – most patients improve with HAART with possible benefit from ARV agents
that penetrate the CNS (AZT, d4T, ABC, Nevarpine)
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Supportive care
Peripheral Neuropathies
Occurs in 1/3 of pts with AIDS
Type:
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Mono neuropathy e.g. Bell’s palsy
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Mononuritis multiplex
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Distal sensory peripheral polyneuropathy (DSPN)
DSPN: Is the most common.
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It may be cause by HIV infection or ART mainly d4T and DDI
109