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Komorowski's Bioinformatics Lab Courses o DCB o KBIB Repositories o Rosetta o PFMS o Ciruvis o Visunet o tfNet o More Base Plug-ins Publications Funding News Members o Group Leader o Group Members o Former Members Home Latest Publications Identification of combinatorial host-specific signatures with a potential to affect host adaptation in influenza A H1N1 and H3N2 subtypes Khaliq Z., Leijon M., Belák S. and Komorowski J.... View All Maps of context-dependent putative regulatory regions and genomic signal interactions Klev Diamanti, Husen M. Umer, Marcin Kruczyk, Mich... View All Latest News The Komorowski lab ski retreat 2017-04-04 14:32:38 Last week our group enjoyed skiing in Kungsberget.... Read More Visit by Ass. Prof. Magdalena Mozolewska 2017-04-03 14:54:36 Magdalena Mozolewska is Assistant Professor in res... Read More Contact us Welcome to Komorowski's BioInformatics Lab The bioinformatics group research is a reflection of the field: on one hand we develop algorithms and build tools and software systems that enable answering complex questions in Life Sciences, on the other hand we try to come with answers to these questions. Our modus of work is distinguished by collaboration. Our flagship is the Rosetta system that implements an environment for developing rough set classifiers from large and very large data collected in decision systems. In recent years we moved towards decision systems with thousands of features and extended our computational framework with Monte Carlo Feature Selection and Random Reducts. Rosetta can now be executed on multicore architecture. We take a step away from univariate and linear thinking and help answer questions which groups of features (variables) and in which combinations contribute most to the outcome (decision). Data in the form of decision tables is omnipresent in Life Sciences. Examples of solved problems in different domains include but are not limited to: functional genomics - how to predict gene’s participation in a biological process from gene expression time profiles and how to assign function to new genes from such profiles; Genome Research and Bioinformatics proteomics - which positions of octamer polypeptides and for what values, ie. amino acids are decisive for cleavage or non-cleavage by HIV protease; Proteins chromatin - what is organization of nucleosomes in gene bodies; Genome Research medicine - which gene-gene pairs and with which environmental factors interact in allergy; PLoS One epigenetics - what are combinatorial associations of histone modifications to exon expression; PLoS One Our present interest is in transcriptomics with a particular focus on the interplay of chromatin structure and DNA and their modifications. Of major interest are common mechanisms behind common disease such as diabetes type II, gliomas and cervix cancer. We also continue our work in proteomics and virology, and, it goes without saying, on the algorithms and tools. Our main collaborators are: Professor Claes Wadelius, Department of Immunology, Genetics and Pathology, Uppsala University Professor Jacek Koronacki, Institute of Computer Science, Polish Academy of Sciences Professor Bozena Kaminska, The Nencki Institute of Experimental Biology, Polish Academy of Sciences. Copyright © 2017 Komorowski's BioInformatics Lab, Uppsala University | developed by Klev Diamanti | design from HTML5webtemplates.co.uk