Download BILL #37: Learning Guide: Chromosome Behavior and LInked Genes

Learning Guide: Chromosome Behavior and Linked Genes
Bill Activity #38
To Think About: How does the behavior of chromosomes support Mendelian inheritance patterns? How
does linkage affect inheritance? How does the chromosomal basis of recombination generate variation?
What is the connection between new combinations of alleles and evolution?
1st Interact: Take notes on Mr. Andersen’s Mechanisms That Increase Genetic Variation Video
This video addresses how prokaryotes and eukaryotes increase genetic variation. The
eukaryotic portion is a review of what was discussed in class.
2nd Read About: Chromosomes: Pgs. 286-292 Campbell’s Biology 9th edition
 Overview: Describe what Mendel’s “hereditary factors” are.
 Mendelian inheritance has its physical basis in the behavior of chromosomes.
o Explain the chromosome theory of inheritance.
o Create a sketch to demonstrate the concept of the law of segregation and the law of
independent assortment occurring to chromosomes in a cell or two
 Morgan’s experimental evidence
o List at least three reasons why the fruit fly is an excellent subject for genetic studies.
o Explain the notation to indicated fruit fly genotypes
o Describe how Morgan determined that the eye color trait was located on the X
chromosome.
 Sex linked genes
o Define the following: SRY gene, sex-linked gene, Y-linked gene, X-linked gene
o Name and describe three sex linked disorders
o Explain Barr bodies and X-inactivation.
 Linked genes
o Describe how linkage affects inheritance and linked genes
o Explain the difference between recombination of unlinked genes and recombination of
linked genes
o Explain how the new combination of alleles affects natural selection
o Describe what a genetic map is and how they are constructed. Include an explanation of
a linkage map and map units.
3rd Interact Take notes on Mr. Andersen’s Linked Genes Video
Supplementary Resources: Click the links below for more information to help you learn more about this
lesson.
 Hillis et al.:Independent Assortment of Alleles Animation
 University of Arizona Biology Project: Sex-Linked Problem Set
Learn More: For more information about inheritance of traits and production of gametes, follow the
links below:
 Queen Victoria and Hemophilia: Trace the passage of hemophilia through the royal families of
Europe