Download MCQs: What cell types can be made tolerant? T

MCQs:
1. What cell types can be made tolerant?
(a) T-cells alone
(C)T and B cell
(b) B-cells alone
(d) macrophage
2. The major step in inducing T-cell tolerance occurs in :
(a) Thymus
(b) bone marrow
(C) Spleen
(d) lymph nodes
3. Very high doses of antigen induce:
(a) Negative selection
(b) clonal deletion
(C)Immune paralysis
(d) Positive selection
* Very high doses of antigen induce form of tolerance known as immune paralysis
4. Aged red cells are removed by the autoantibodies against:
(a) Band 3 protien
(b) type O blood group
(C) complement
(d) idiotypes
5. Some autoimmune disease may result from cross-reactions between organisms and tissues.
(a) Clonal anergy
(b) tissues sensitization
(C) antigenic variation
(d) molecular mimicry
6. Systemic Lupus erythematosus is most characteristically associated with:
(a)Rheumatoid arthritis
(C) Neutrophils
(b) antinuclear antibodies
(d) lymphoid cell tumour
7. When a T cell is made tolerant by receiving inappropriate co-stimulation, it is called:
(a) Positive selection
(b)clonal selection
(C) clonal anergy
(d) negative selection
8. The autoimmune disease are caused by:
(a) a defect in thymus development
(b) a defect in the cell mediated immune system
(C) a defect in the antibodies mediated immune system
(d) an immune response against self-antigens
9.Which one of the following statement is true?
(a) The thymus controls peripheral tolerance of T cells
(b) No self-reactive T cells can be found in healthy normal subjects.
(c) Naïve T cells need more than one signal in order to become activated
(d) B-cell tolerance is more important than T-cell tolerance in the prevention of autoimmunity
(e) class II MHC molecules are expressed on most cells
10. All the following sentences are true about tolerance breakdown except:
(a) Following administration of an immunological adjuvant
(b) After IL 2 treatment
(c) By a process of molecular mimicry
(d) After surgical removal of the thymus in the first year of life in humans
(e) If there is abnormal expression of the AIRE gene in the thymus
11. All the following sentences are true regarding genetic defects of the immune system except:
(a) Fas deficiency in human causes lymphadenopathy and thrombocytopenia
(b) C1q deficiency is associated with systemic endocrine erythematosus
(c) Mutations of the AIRE gene are associated with endocrine autoimmunity
(d) Overexpression of TNF-α in transgenic mice is associated with inflammatory arthritis
(e) CD40 ligand deficiency in humans associated with primary biliary cirrhosis
12. Cryptic T-cell epitopes capable of triggering autoimmune disease:
(a)
(b)
(c)
(d)
(e)
Dominate the normal immune response
Negatively select T-cells
Are unable to bind in the MHC groove.
Can be derived by antigen processing.
Are presented by MHC class I but not MHC class II molecules
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