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Transcript
A) The linearized double-stranded DNA genome of KS virus showing important genes of the lytic cycle. The genome contains 87 open reading frames (ORFs) coding for latent proteins, reactivation proteins, and structural proteins. Host genes that help the virus evade immune surveillance and inhibit apoptosis have been acquired from chromosomes through a process of molecular piracy. These genes include vFLIP, vBcl-2, v-cyclin, interferon response factors (IRFs), and membrane cofactor protein (MCP), v-IL6, macrophage inflammatory protein (MIP) chemokines, LANA, and v-IL8R (vGCR). Genes specifying LANA, K1/KIST, and K15/LAMP maintain the viral episome in the latent state and are analogous to EBV proteins (EBNA1, LMP1, LMP2) with similar functions. B to E) Skin lesions associated with KS. Lesions present as red blotches on the skin caused by the infection of spindle cells. Source: Oncogenic Viruses and Tumor Viruses, The Basic Science of Oncology, 5e Angiogenesis occurs in the surrounding tissue. Panels B and C are examples of endemic or Mediterranean KS, while panels D and E illustrate epidemic or Tannock IF, Hill RP, Bristow RG, Harrington L. The Basic Science of Oncology, 5e; 2016 Available at: http://mhmedical.com/ AIDS-relatedCitation: KS. Accessed: August 11, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved