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Download Dr. József Kónya, MD, PhD head Dept. Medical Microbiology Faculty
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Dr. József Kónya, MD, PhD head Dept. Medical Microbiology Faculty of Medicine, University of Debrecen E-mail: [email protected] RE: RECOOP Visegrad Scholarship – Dept. Medical Microbiology, Debrecen, Hungary HPV epigenetic study High-risk human papillomaviruses (HPV) are necessary cause of cervical cancer, a malignancy with expectedly high incidence also in the next decades. The E6 and E7 papillomaviral oncoproteins immortalize the host cell by stimulating the cell cycle, induce genomic instability and alterations in gene expression profile of the host cell. The oncogenic effect of the E6 and E7 oncoproteins is necessary also for maintaining the malignant phenotype. This proposal targets two aspects of the central oncogenic role of HPV. One aspect is to identify molecular mechanisms that are responsible for the gene expression alterations by HPV oncoproteins, which may be useful in the diagnosis or prognosis of HPV associated malignant and premalignant diseases. Precise mapping of the interaction between viral oncoproteins and promoters of host genes can explore new targets to block the uncontrolled cellular pathways of the malignant cells. The other aspect of the proposal is that detection of epigenetic and transcriptional regulatory mechanisms of the HPV genome can serve as biomarkers of viral oncogene expression. In the individual patient care and diagnostic, a panel of these biomarkers can sensitively and specifically detect the malignancy associated functional state of HPV genome. Potential Applicants RECOOP Intra-Visegrad Scholarships: Slovak Medical University, Bratislava, Slovakia University Hospital in Hradec Kralove, Czech Republic Comenius University in Bratislava, Slovakia The Intra-Visegrad Scholarships scheme is suitable for scholars coming from one of the Visegrad Group (V4) countries (the Czech Republic, Hungary, Poland or Slovakia) who plan to study in any V4 country other than that of their citizenship (at any accredited public or private university or institute of the respective national academies of sciences) Successful applicants within this scheme will receive scholarships of €2,300/semester and the corresponding host universities/institutes receive €1,500/semester/scholar. RECOOP Matching Fund €1,000/semester/scholar Potential Applicants RECOOP In-Coming Scholarship Danylo Halytsky Lviv National Medical University, Lviv, Ukraine In-Coming Scholarship - Scholarships for Eastern Partnership Scholarships for EaP are an extension of the existing In-Coming scheme of the Visegrad Scholarship Program financing individual mobility of EaP scholars (citizens of Armenia, Azerbaijan, Belarus, Georgia, Moldova or Ukraine) to pursue study or research stays at accredited public or private colleges or universities in the V4 countries. Successful applicants within this scheme will receive scholarships of €2,300/semester and the corresponding host universities/institutes receive €1,500/semester/scholar. Scholars who will have to travel to the host institution more than 1,500 km are also eligible for one-time Travel Grant. RECOOP Matching Fund €1,000/semester/scholar