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Download Molecular mechanisms of the epigenetic regulation Tatiana G
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Transcript
Molecular mechanisms of the epigenetic regulation Tatiana G. Kutateladze Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045 USA Plant homeodomain (PHD) fingers, YEATS, Tudor and bromodomains are found in proteins involved in a wide array of fundamental biological processes, including transcription, replication, DNA damage repair, cell differentiation and survival. These domains comprise the largest families of epigenetic readers, capable of recognizing PTMs (posttranslational modifications) in histones. Here, I will detail the binding mechanisms and biological functions of the readers that select for methylated, acetylated, and unmodified histone H3 tails. I will compare specificities and discuss the significance of crosstalk between PTMs and the consequence of combinatorial readout for the recruitment of these readers to chromatin.
