Download Chapter 18 Quantitative and Thought Questions 18.1 Both would be

Chapter 18
Quantitative and Thought Questions
18.1 Both would be impaired because T cells would not differentiate. The absence of cytotoxic T cells
would eliminate responses mediated by these cells. The absence of helper T cells would impair
antibody-mediated responses because most B cells require cytokines from helper T cells to become
activated.
18.2 Neutrophil deficiency would impair nonspecific (innate) inflammatory responses to bacteria.
Monocyte deficiency, by causing macrophage deficiency, would impair both innate inflammation and
adaptive immune responses.
18.3 The drug may reduce but would not eliminate the action of complement, because this system
destroys cells directly (via the membrane attack complex) as well as by facilitating phagocytosis.
18.4 Antibodies would bind normally to antigen but may not be able to activate complement, act as
opsonins, or recruit NK cells in ADCC. The reason for these defects is that the sites to which complement
C1, phagocytes, and NK cells bind are all located in the Fc portion of antibodies.
18.5 They do develop fever, although often not to the same degree as normal. They can do so because
IL-1 and other cytokines secreted by macrophages cause fever, whereas the defect in AIDS is failure of
helper T-cell function.
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