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Lecture 1 1. Why don’t pattern recognition receptors on human phagocytic cells lead to damage of the human host? 2. Discuss the primary differences between innate and adaptive immune system. 3. Discuss the kinetics of a primary immune response. 4. How does the secondary immune response distinguish itself from a primary immune response? Lecture 2 1. The complement system gives rise to inflammatory signals, opsonins and molecules that lyse bacteria. Describe those molecules. Say which do you think is the most important for host defense? 2. The complement system is a cascade of enzymes capable of producing powerful deleterious effects. How is complement harnessed to protect us rather than creating harm? 3. During their development and in order to perform their various functions efficiently cells of the immune system must find their way to the correct part of the body. How do they manage to do this? 4. Innate immunity collaborates with adaptive immunity to protect the host. Discuss this collaboration, naming key points of interaction between the two systems. 5. What are the hallmarks of the localized inflammatory response? How do these characteristics contribute to the mounting of an effective innate immune response?